Cargando…

Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines

Microtubules are currently ranked one of the most validated targets for chemotherapy; with clinical use of microtubule targeting agents (MTAs) extending beyond half a century. Recent research has focused on the development of novel MTAs to combat drug resistance and drug associated toxicities. Of pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Greene, LM, Butini, S, Campiani, G, Williams, DC, Zisterer, DM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166549/ https://www.ncbi.nlm.nih.gov/pubmed/27994676 http://dx.doi.org/10.7150/jca.16616

Ejemplares similares

The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells
por: NATHWANI, SEEMA-MARIA, et al.
Publicado: (2016)

Pyrrolo-1,5-Benzoxazepines Induce Apoptosis in Chronic Myeloid Leukemia (CML) Cells by Bypassing the Apoptotic Suppressor BCR-ABL
por: Mc Gee, Margaret M., et al.
Publicado: (2001)

Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo
por: Bright, S A, et al.
Publicado: (2010)

PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells
por: Maginn, E N, et al.
Publicado: (2011)

8-Chloro-5-(4-phenethylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine
por: Capuano, Ben, et al.
Publicado: (2008)

Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones — Effect of the Halogen of (2S)-α-Haloacids
por: Rubab, Syeda Laila, et al.
Publicado: (2013)

Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
por: Cruz-López, Olga, et al.
Publicado: (2021)

Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction
por: Tóth, László, et al.
Publicado: (2014)

A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles
por: Battah, Basem, et al.
Publicado: (2019)

Computational Tool for Fast in silico Evaluation of hERG K(+) Channel Affinity
por: Chemi, Giulia, et al.
Publicado: (2017)

[1,5]-Hydride Shift-Cyclization versus C(sp(2))-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines
por: Szalóki Vargáné, Dóra, et al.
Publicado: (2020)

Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents
por: Dave, Chaitanya G., et al.
Publicado: (2002)

Base-Promoted Chemodivergent Formation of 1,4-Benzoxazepin-5(4H)-ones and 1,3-Benzoxazin-4(4H)-ones Switched by Solvents
por: Chen, Qian, et al.
Publicado: (2019)

Enantioenriched α-Vinyl 1,4-Benzodiazepines and 1,4-Benzoxazepines via Enantioselective Rhodium-Catalyzed Hydrofunctionalizations of Alkynes and Allenes
por: Velasco-Rubio, Álvaro, et al.
Publicado: (2021)

A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors
por: Fontana, Anna, et al.
Publicado: (2022)

N-Cyclohexyl-5H,7H-13,15-dimethyl-9-nitro-5-oxophenanthrido[4,4a,5-bc][1,4]benzoxazepine-7-carboxamide
por: Luo, Jia-Lu, et al.
Publicado: (2009)

Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer
por: Ana, Gloria, et al.
Publicado: (2021)

Transition Metal Complexes of Quinolino[3,2-b]benzodiazepine and Quinolino[3,2-b]benzoxazepine: Synthesis, Characterization, and Antimicrobial Studies
por: Basavaraju, B., et al.
Publicado: (2007)

Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity
por: Colangeli, Roberto, et al.
Publicado: (2018)

The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity
por: Colangeli, Roberto, et al.
Publicado: (2017)

Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity
por: Colangeli, Roberto, et al.
Publicado: (2018)

Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides
por: Klimenko, Anna A., et al.
Publicado: (2018)

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases
por: Maramai, Samuele, et al.
Publicado: (2016)

Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases
por: Brogi, Simone, et al.
Publicado: (2022)

mTOR inhibitors: A novel class of anti-cancer agents
por: Riaz, Haris, et al.
Publicado: (2012)

5-Bromo-1H-pyrrolo[2,3-b]pyridine
por: Štarha, Pavel, et al.
Publicado: (2013)

Design and Synthesis of Pyrrolo[2,1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents
por: Kakhki, Samaneh, et al.
Publicado: (2016)

Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach
por: Amărandi, Roxana-Maria, et al.
Publicado: (2023)

Sequential Annulations to Interesting Novel Pyrrolo[3,2-c]carbazoles
por: Benzi, Alice, et al.
Publicado: (2019)

Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity
por: Pozzetti, Luca, et al.
Publicado: (2022)

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
por: Papa, Alessandro, et al.
Publicado: (2022)

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery
por: Marotta, Ludovica, et al.
Publicado: (2022)

Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents
por: Tang, Sheng, et al.
Publicado: (2017)

Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells
por: Ramírez, Alberto, et al.
Publicado: (2018)

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
por: Popovici, Lacramioara, et al.
Publicado: (2019)

Identification of Spiro-Fused Pyrrolo[3,4-a]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation
por: Latypova, Diana K., et al.
Publicado: (2021)

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
por: Sirous, Hajar, et al.
Publicado: (2019)

Pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dithione
por: Ourahou, Sarah, et al.
Publicado: (2010)

Synthesis of pyrrolo[3,2-a]phenazines from 5-nitroindoles and anilines
por: Wróbel, Zbigniew, et al.
Publicado: (2013)

Contributing to Biochemistry and Optoelectronics: Pyrrolo[1′,2′:2,3]imidazo[1,5-a]indoles and Cyclohepta[4,5]pyrrolo[1,2-c]pyrrolo[1,2-a]imidazoles via [3+2] Annulation of Acylethynylcycloalka[b]pyrroles with Δ(1)-Pyrrolines
por: Oparina, Ludmila A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sc8i91ubpipckpgt02g54teaqj