Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-trigge...

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Autores principales: Dondi, R., Yaghini, E., Tewari, K. M., Wang, L., Giuntini, F., Loizidou, M., MacRobert, A. J., Eggleston, I. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166568/
https://www.ncbi.nlm.nih.gov/pubmed/27886311
http://dx.doi.org/10.1039/c6ob02135b
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author Dondi, R.
Yaghini, E.
Tewari, K. M.
Wang, L.
Giuntini, F.
Loizidou, M.
MacRobert, A. J.
Eggleston, I. M.
author_facet Dondi, R.
Yaghini, E.
Tewari, K. M.
Wang, L.
Giuntini, F.
Loizidou, M.
MacRobert, A. J.
Eggleston, I. M.
author_sort Dondi, R.
collection PubMed
description Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
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spelling pubmed-51665682016-12-21 Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy Dondi, R. Yaghini, E. Tewari, K. M. Wang, L. Giuntini, F. Loizidou, M. MacRobert, A. J. Eggleston, I. M. Org Biomol Chem Chemistry Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT). Royal Society of Chemistry 2016-12-28 2016-11-14 /pmc/articles/PMC5166568/ /pubmed/27886311 http://dx.doi.org/10.1039/c6ob02135b Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Dondi, R.
Yaghini, E.
Tewari, K. M.
Wang, L.
Giuntini, F.
Loizidou, M.
MacRobert, A. J.
Eggleston, I. M.
Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
title Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
title_full Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
title_fullStr Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
title_full_unstemmed Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
title_short Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
title_sort flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166568/
https://www.ncbi.nlm.nih.gov/pubmed/27886311
http://dx.doi.org/10.1039/c6ob02135b
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