Human leucocyte antigen class I‐redirected anti‐tumour CD4(+) T cells require a higher T cell receptor binding affinity for optimal activity than CD8(+) T cells

CD4(+) T helper cells are a valuable component of the immune response towards cancer. Unfortunately, natural tumour‐specific CD4(+) T cells occur in low frequency, express relatively low‐affinity T cell receptors (TCRs) and show poor reactivity towards cognate antigen. In addition, the lack of human...

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Detalles Bibliográficos
Autores principales: Tan, M. P., Dolton, G. M., Gerry, A. B., Brewer, J. E., Bennett, A. D., Pumphrey, N. J., Jakobsen, B. K., Sewell, A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167017/
https://www.ncbi.nlm.nih.gov/pubmed/27324616
http://dx.doi.org/10.1111/cei.12828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167017/
https://www.ncbi.nlm.nih.gov/pubmed/27324616
http://dx.doi.org/10.1111/cei.12828

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