Gut flora connects obesity with pathological angiogenesis in the eye

Neovascular age‐related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well‐known predisposing factor for nvAMD but how this metabolic disorder modulate...

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Detalles Bibliográficos
Autores principales: Scholz, Rebecca, Langmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167127/
https://www.ncbi.nlm.nih.gov/pubmed/27861130
http://dx.doi.org/10.15252/emmm.201607165
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author Scholz, Rebecca
Langmann, Thomas
author_facet Scholz, Rebecca
Langmann, Thomas
author_sort Scholz, Rebecca
collection PubMed
description Neovascular age‐related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well‐known predisposing factor for nvAMD but how this metabolic disorder modulates angiogenesis in the posterior eye segment was largely unknown. In this issue of EMBO Molecular Medicine, Andriessen et al (2016) show that high‐fat diet‐induced obesity causes dysbiosis in the gut that drives retinal inflammation and pathological angiogenesis in a mouse model of laser‐induced choroidal neovascularization (CNV).
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spelling pubmed-51671272016-12-28 Gut flora connects obesity with pathological angiogenesis in the eye Scholz, Rebecca Langmann, Thomas EMBO Mol Med News & Views Neovascular age‐related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well‐known predisposing factor for nvAMD but how this metabolic disorder modulates angiogenesis in the posterior eye segment was largely unknown. In this issue of EMBO Molecular Medicine, Andriessen et al (2016) show that high‐fat diet‐induced obesity causes dysbiosis in the gut that drives retinal inflammation and pathological angiogenesis in a mouse model of laser‐induced choroidal neovascularization (CNV). John Wiley and Sons Inc. 2016-11-15 2016-12 /pmc/articles/PMC5167127/ /pubmed/27861130 http://dx.doi.org/10.15252/emmm.201607165 Text en © 2016 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Scholz, Rebecca
Langmann, Thomas
Gut flora connects obesity with pathological angiogenesis in the eye
title Gut flora connects obesity with pathological angiogenesis in the eye
title_full Gut flora connects obesity with pathological angiogenesis in the eye
title_fullStr Gut flora connects obesity with pathological angiogenesis in the eye
title_full_unstemmed Gut flora connects obesity with pathological angiogenesis in the eye
title_short Gut flora connects obesity with pathological angiogenesis in the eye
title_sort gut flora connects obesity with pathological angiogenesis in the eye
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167127/
https://www.ncbi.nlm.nih.gov/pubmed/27861130
http://dx.doi.org/10.15252/emmm.201607165
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AT langmannthomas gutfloraconnectsobesitywithpathologicalangiogenesisintheeye

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