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Further intracellular proteins and signaling pathways regulated by angiotensin-(1–7) in human endothelial cells

In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1–7) and the first 10 intracellular signaling cascades at different time points. This suppo...

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Detalles Bibliográficos
Autores principales: Meinert, Christian, Kohse, Franziska, Böhme, Ilka, Gembardt, Florian, Tetzner, Anja, Wieland, Thomas, Greenberg, Barry, Walther, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167237/
https://www.ncbi.nlm.nih.gov/pubmed/28018949
http://dx.doi.org/10.1016/j.dib.2016.12.004
Descripción
Sumario:In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1–7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1–7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1–7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.