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Chiral Brønsted Acid‐Catalyzed Enantioselective α‐Amidoalkylation Reactions: A Joint Experimental and Predictive Study

Enamides with a free NH group have been evaluated as nucleophiles in chiral Brønsted acid‐catalyzed enantioselective α‐amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters. A quantitative structure–reactivity relationship (QSRR) method has been develope...

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Detalles Bibliográficos
Autores principales:	Aranzamendi, Eider, Arrasate, Sonia, Sotomayor, Nuria, González‐Díaz, Humberto, Lete, Esther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167290/ https://www.ncbi.nlm.nih.gov/pubmed/28032023 http://dx.doi.org/10.1002/open.201600120

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