Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)

The Front Cover picture shows a colorimetric single‐nucleotide polymorphism (SNP) genotyping method using spontaneous aggregation of DNA‐modified gold nanoparticles (DNA–AuNPs). Simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene is reported. Allele‐specific single‐base primer extension using a fragment of the gene isolated from human hair roots, followed by salt‐induced aggregation of DNA–AuNPs, results in a rapid color change from red to blue or no color change, thereby allowing SNP discrimination by the naked eye. More information can be found in the Communication by T. Takarada and co‐workers on page 508 in Issue 6, 2016 (DOI: 10.1002/open.201600110).[Image: see text]