Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)

The Front Cover picture shows a colorimetric single‐nucleotide polymorphism (SNP) genotyping method using spontaneous aggregation of DNA‐modified gold nanoparticles (DNA–AuNPs). Simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene is reported. Allele‐specific single‐b...

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Autores principales: Akiyama, Yoshitsugu, Wang, Guoqing, Shiraishi, Shota, Kanayama, Naoki, Takarada, Tohru, Maeda, Mizuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cover Pictures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167331/
http://dx.doi.org/10.1002/open.201600143
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author Akiyama, Yoshitsugu
Wang, Guoqing
Shiraishi, Shota
Kanayama, Naoki
Takarada, Tohru
Maeda, Mizuo
author_facet Akiyama, Yoshitsugu
Wang, Guoqing
Shiraishi, Shota
Kanayama, Naoki
Takarada, Tohru
Maeda, Mizuo
author_sort Akiyama, Yoshitsugu
collection PubMed
description The Front Cover picture shows a colorimetric single‐nucleotide polymorphism (SNP) genotyping method using spontaneous aggregation of DNA‐modified gold nanoparticles (DNA–AuNPs). Simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene is reported. Allele‐specific single‐base primer extension using a fragment of the gene isolated from human hair roots, followed by salt‐induced aggregation of DNA–AuNPs, results in a rapid color change from red to blue or no color change, thereby allowing SNP discrimination by the naked eye. More information can be found in the Communication by T. Takarada and co‐workers on page 508 in Issue 6, 2016 (DOI: 10.1002/open.201600110).[Image: see text]
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spelling pubmed-51673312016-12-28 Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016) Akiyama, Yoshitsugu Wang, Guoqing Shiraishi, Shota Kanayama, Naoki Takarada, Tohru Maeda, Mizuo ChemistryOpen Cover Pictures The Front Cover picture shows a colorimetric single‐nucleotide polymorphism (SNP) genotyping method using spontaneous aggregation of DNA‐modified gold nanoparticles (DNA–AuNPs). Simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene is reported. Allele‐specific single‐base primer extension using a fragment of the gene isolated from human hair roots, followed by salt‐induced aggregation of DNA–AuNPs, results in a rapid color change from red to blue or no color change, thereby allowing SNP discrimination by the naked eye. More information can be found in the Communication by T. Takarada and co‐workers on page 508 in Issue 6, 2016 (DOI: 10.1002/open.201600110).[Image: see text] John Wiley and Sons Inc. 2016-11-15 /pmc/articles/PMC5167331/ http://dx.doi.org/10.1002/open.201600143 Text en © 2016 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
spellingShingle Cover Pictures
Akiyama, Yoshitsugu
Wang, Guoqing
Shiraishi, Shota
Kanayama, Naoki
Takarada, Tohru
Maeda, Mizuo
Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)
title Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)
title_full Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)
title_fullStr Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)
title_full_unstemmed Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)
title_short Cover Picture: Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles (ChemistryOpen 6/2016)
title_sort cover picture: rapid naked‐eye discrimination of cytochrome p450 genetic polymorphism through non‐crosslinking aggregation of dna‐functionalized gold nanoparticles (chemistryopen 6/2016)
topic Cover Pictures
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167331/
http://dx.doi.org/10.1002/open.201600143
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