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Compact NMR relaxometry of human blood and blood components

Nuclear magnetic resonance relaxometry is a uniquely practical and versatile implementation of NMR technology. Because it does not depend on chemical shift resolution, it can be performed using low-field compact instruments deployed in atypical settings. Early relaxometry studies of human blood were...

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Autores principales: Cistola, David P., Robinson, Michelle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167358/
https://www.ncbi.nlm.nih.gov/pubmed/28003711
http://dx.doi.org/10.1016/j.trac.2016.04.020
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author Cistola, David P.
Robinson, Michelle D.
author_facet Cistola, David P.
Robinson, Michelle D.
author_sort Cistola, David P.
collection PubMed
description Nuclear magnetic resonance relaxometry is a uniquely practical and versatile implementation of NMR technology. Because it does not depend on chemical shift resolution, it can be performed using low-field compact instruments deployed in atypical settings. Early relaxometry studies of human blood were focused on developing a diagnostic test for cancer. Those efforts were misplaced, as the measurements were not specific to cancer. However, important lessons were learned about the factors that drive the water longitudinal (T(1)) and transverse (T(2)) relaxation times. One key factor is the overall distribution of proteins and lipoproteins. Plasma water T(2) can detect shifts in the blood proteome resulting from inflammation, insulin resistance and dyslipidemia. In whole blood, T(2) is sensitive to hemoglobin content and oxygenation, although the latter can be suppressed by manipulating the static and applied magnetic fields. Current applications of compact NMR relaxometry include blood tests for candidiasis, hemostasis, malaria and insulin resistance.
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spelling pubmed-51673582016-12-19 Compact NMR relaxometry of human blood and blood components Cistola, David P. Robinson, Michelle D. Trends Analyt Chem Article Nuclear magnetic resonance relaxometry is a uniquely practical and versatile implementation of NMR technology. Because it does not depend on chemical shift resolution, it can be performed using low-field compact instruments deployed in atypical settings. Early relaxometry studies of human blood were focused on developing a diagnostic test for cancer. Those efforts were misplaced, as the measurements were not specific to cancer. However, important lessons were learned about the factors that drive the water longitudinal (T(1)) and transverse (T(2)) relaxation times. One key factor is the overall distribution of proteins and lipoproteins. Plasma water T(2) can detect shifts in the blood proteome resulting from inflammation, insulin resistance and dyslipidemia. In whole blood, T(2) is sensitive to hemoglobin content and oxygenation, although the latter can be suppressed by manipulating the static and applied magnetic fields. Current applications of compact NMR relaxometry include blood tests for candidiasis, hemostasis, malaria and insulin resistance. 2016-11 /pmc/articles/PMC5167358/ /pubmed/28003711 http://dx.doi.org/10.1016/j.trac.2016.04.020 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Cistola, David P.
Robinson, Michelle D.
Compact NMR relaxometry of human blood and blood components
title Compact NMR relaxometry of human blood and blood components
title_full Compact NMR relaxometry of human blood and blood components
title_fullStr Compact NMR relaxometry of human blood and blood components
title_full_unstemmed Compact NMR relaxometry of human blood and blood components
title_short Compact NMR relaxometry of human blood and blood components
title_sort compact nmr relaxometry of human blood and blood components
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167358/
https://www.ncbi.nlm.nih.gov/pubmed/28003711
http://dx.doi.org/10.1016/j.trac.2016.04.020
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