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Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 e...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167462/ https://www.ncbi.nlm.nih.gov/pubmed/28008222 http://dx.doi.org/10.2147/OPTH.S120402 |
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author | Suetsugu, Tetsuyuki Kato, Aki Yoshida, Munenori Yasukawa, Tsutomu Nishiwaki, Akiko Hasegawa, Norio Usui, Hideaki Ogura, Yuichiro |
author_facet | Suetsugu, Tetsuyuki Kato, Aki Yoshida, Munenori Yasukawa, Tsutomu Nishiwaki, Akiko Hasegawa, Norio Usui, Hideaki Ogura, Yuichiro |
author_sort | Suetsugu, Tetsuyuki |
collection | PubMed |
description | PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. RESULTS: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. CONCLUSION: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes. |
format | Online Article Text |
id | pubmed-5167462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51674622016-12-22 Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration Suetsugu, Tetsuyuki Kato, Aki Yoshida, Munenori Yasukawa, Tsutomu Nishiwaki, Akiko Hasegawa, Norio Usui, Hideaki Ogura, Yuichiro Clin Ophthalmol Original Research PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. RESULTS: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. CONCLUSION: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes. Dove Medical Press 2016-12-14 /pmc/articles/PMC5167462/ /pubmed/28008222 http://dx.doi.org/10.2147/OPTH.S120402 Text en © 2016 Suetsugu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Suetsugu, Tetsuyuki Kato, Aki Yoshida, Munenori Yasukawa, Tsutomu Nishiwaki, Akiko Hasegawa, Norio Usui, Hideaki Ogura, Yuichiro Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
title | Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
title_full | Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
title_fullStr | Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
title_full_unstemmed | Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
title_short | Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
title_sort | evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167462/ https://www.ncbi.nlm.nih.gov/pubmed/28008222 http://dx.doi.org/10.2147/OPTH.S120402 |
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