Cargando…

Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration

PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 e...

Descripción completa

Detalles Bibliográficos
Autores principales: Suetsugu, Tetsuyuki, Kato, Aki, Yoshida, Munenori, Yasukawa, Tsutomu, Nishiwaki, Akiko, Hasegawa, Norio, Usui, Hideaki, Ogura, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167462/
https://www.ncbi.nlm.nih.gov/pubmed/28008222
http://dx.doi.org/10.2147/OPTH.S120402
_version_ 1782483181617807360
author Suetsugu, Tetsuyuki
Kato, Aki
Yoshida, Munenori
Yasukawa, Tsutomu
Nishiwaki, Akiko
Hasegawa, Norio
Usui, Hideaki
Ogura, Yuichiro
author_facet Suetsugu, Tetsuyuki
Kato, Aki
Yoshida, Munenori
Yasukawa, Tsutomu
Nishiwaki, Akiko
Hasegawa, Norio
Usui, Hideaki
Ogura, Yuichiro
author_sort Suetsugu, Tetsuyuki
collection PubMed
description PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. RESULTS: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. CONCLUSION: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes.
format Online
Article
Text
id pubmed-5167462
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-51674622016-12-22 Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration Suetsugu, Tetsuyuki Kato, Aki Yoshida, Munenori Yasukawa, Tsutomu Nishiwaki, Akiko Hasegawa, Norio Usui, Hideaki Ogura, Yuichiro Clin Ophthalmol Original Research PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. RESULTS: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. CONCLUSION: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes. Dove Medical Press 2016-12-14 /pmc/articles/PMC5167462/ /pubmed/28008222 http://dx.doi.org/10.2147/OPTH.S120402 Text en © 2016 Suetsugu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Suetsugu, Tetsuyuki
Kato, Aki
Yoshida, Munenori
Yasukawa, Tsutomu
Nishiwaki, Akiko
Hasegawa, Norio
Usui, Hideaki
Ogura, Yuichiro
Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_full Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_fullStr Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_full_unstemmed Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_short Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_sort evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167462/
https://www.ncbi.nlm.nih.gov/pubmed/28008222
http://dx.doi.org/10.2147/OPTH.S120402
work_keys_str_mv AT suetsugutetsuyuki evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT katoaki evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT yoshidamunenori evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT yasukawatsutomu evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT nishiwakiakiko evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT hasegawanorio evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT usuihideaki evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
AT ogurayuichiro evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration