Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report

A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vita...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurita, Masatake, Moriya, Takahiro, Nishino, Satoshi, Hirata, Eishin, Hirasawa, Noriyasu, Okubo, Yoshiro, Sato, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167487/
https://www.ncbi.nlm.nih.gov/pubmed/28008257
http://dx.doi.org/10.2147/NDT.S115648
Descripción
Sumario:A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms.

Ejemplares similares