Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report

A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vita...

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Autores principales: Kurita, Masatake, Moriya, Takahiro, Nishino, Satoshi, Hirata, Eishin, Hirasawa, Noriyasu, Okubo, Yoshiro, Sato, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167487/
https://www.ncbi.nlm.nih.gov/pubmed/28008257
http://dx.doi.org/10.2147/NDT.S115648
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author Kurita, Masatake
Moriya, Takahiro
Nishino, Satoshi
Hirata, Eishin
Hirasawa, Noriyasu
Okubo, Yoshiro
Sato, Tadahiro
author_facet Kurita, Masatake
Moriya, Takahiro
Nishino, Satoshi
Hirata, Eishin
Hirasawa, Noriyasu
Okubo, Yoshiro
Sato, Tadahiro
author_sort Kurita, Masatake
collection PubMed
description A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms.
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spelling pubmed-51674872016-12-22 Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report Kurita, Masatake Moriya, Takahiro Nishino, Satoshi Hirata, Eishin Hirasawa, Noriyasu Okubo, Yoshiro Sato, Tadahiro Neuropsychiatr Dis Treat Case Report A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms. Dove Medical Press 2016-12-13 /pmc/articles/PMC5167487/ /pubmed/28008257 http://dx.doi.org/10.2147/NDT.S115648 Text en © 2016 Kurita et al. This work is published and licensed by Dove Medical Press Limited TThe full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Kurita, Masatake
Moriya, Takahiro
Nishino, Satoshi
Hirata, Eishin
Hirasawa, Noriyasu
Okubo, Yoshiro
Sato, Tadahiro
Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_full Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_fullStr Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_full_unstemmed Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_short Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_sort non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167487/
https://www.ncbi.nlm.nih.gov/pubmed/28008257
http://dx.doi.org/10.2147/NDT.S115648
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