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The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future

BACKGROUND: To evaluate the association between mood and anxiety disorders and thyroid autoimmunity in a community sample. Methods: A community based sample of 222 subjects was examined. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview Simplified (CIDIS),...

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Autores principales: Carta, Mauro Giovanni, Loviselli, Andrea, Hardoy, Maria Carolina, Massa, Sergio, Cadeddu, Mariangela, Sardu, Claudia, Carpiniello, Bernardo, Dell'Osso, Liliana, Mariotti, Stefano
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516779/
https://www.ncbi.nlm.nih.gov/pubmed/15317653
http://dx.doi.org/10.1186/1471-244X-4-25
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author Carta, Mauro Giovanni
Loviselli, Andrea
Hardoy, Maria Carolina
Massa, Sergio
Cadeddu, Mariangela
Sardu, Claudia
Carpiniello, Bernardo
Dell'Osso, Liliana
Mariotti, Stefano
author_facet Carta, Mauro Giovanni
Loviselli, Andrea
Hardoy, Maria Carolina
Massa, Sergio
Cadeddu, Mariangela
Sardu, Claudia
Carpiniello, Bernardo
Dell'Osso, Liliana
Mariotti, Stefano
author_sort Carta, Mauro Giovanni
collection PubMed
description BACKGROUND: To evaluate the association between mood and anxiety disorders and thyroid autoimmunity in a community sample. Methods: A community based sample of 222 subjects was examined. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview Simplified (CIDIS), according to DSM-IV criteria. All subjects underwent a complete thyroid evaluation including physical examination, thyroid echography and measure of serum free T4 (FT4), free T3 (FT3), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase autoantibodies (anti-TPO). RESULTS: 16.6% of the overall sample had an anti-TPO value above the normal cut-off. Subjects with at least one diagnosis of anxiety disorders (OR = 4.2, C.L. 95% 1.9–38.8) or mood disorders (OR = 2.9, Cl 95% 1.4–6.6, P < 0.011) were positive for serum anti-TPO more frequently than subjects without mood or anxiety disorders. A statistically significant association with anti-TPO+ was found in Anxiety Disorder Not Otherwise Specified (OR = 4.0, CL 95% 1.1–15.5), in Major Depressive Episode (OR = 2.7, CL 95% 1.1–6.7) and Depressive Disorder Not Otherwise Specified (OR = 4.4, S CL 95% 1–19.3). CONCLUSIONS: The study seems to suggest that individuals in the community with thyroid autoimmunity may be at high risk for mood and anxiety disorders. The psychiatric disorders and the autoimmune reaction seem to be rooted in a same (and not easy correctable) aberrancy in the immuno-endocrine system. Should our results be confirmed, the findings may be of great interest for future preventive and case finding projects.
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spelling pubmed-5167792004-09-12 The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future Carta, Mauro Giovanni Loviselli, Andrea Hardoy, Maria Carolina Massa, Sergio Cadeddu, Mariangela Sardu, Claudia Carpiniello, Bernardo Dell'Osso, Liliana Mariotti, Stefano BMC Psychiatry Research Article BACKGROUND: To evaluate the association between mood and anxiety disorders and thyroid autoimmunity in a community sample. Methods: A community based sample of 222 subjects was examined. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview Simplified (CIDIS), according to DSM-IV criteria. All subjects underwent a complete thyroid evaluation including physical examination, thyroid echography and measure of serum free T4 (FT4), free T3 (FT3), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase autoantibodies (anti-TPO). RESULTS: 16.6% of the overall sample had an anti-TPO value above the normal cut-off. Subjects with at least one diagnosis of anxiety disorders (OR = 4.2, C.L. 95% 1.9–38.8) or mood disorders (OR = 2.9, Cl 95% 1.4–6.6, P < 0.011) were positive for serum anti-TPO more frequently than subjects without mood or anxiety disorders. A statistically significant association with anti-TPO+ was found in Anxiety Disorder Not Otherwise Specified (OR = 4.0, CL 95% 1.1–15.5), in Major Depressive Episode (OR = 2.7, CL 95% 1.1–6.7) and Depressive Disorder Not Otherwise Specified (OR = 4.4, S CL 95% 1–19.3). CONCLUSIONS: The study seems to suggest that individuals in the community with thyroid autoimmunity may be at high risk for mood and anxiety disorders. The psychiatric disorders and the autoimmune reaction seem to be rooted in a same (and not easy correctable) aberrancy in the immuno-endocrine system. Should our results be confirmed, the findings may be of great interest for future preventive and case finding projects. BioMed Central 2004-08-18 /pmc/articles/PMC516779/ /pubmed/15317653 http://dx.doi.org/10.1186/1471-244X-4-25 Text en Copyright © 2004 Carta et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Carta, Mauro Giovanni
Loviselli, Andrea
Hardoy, Maria Carolina
Massa, Sergio
Cadeddu, Mariangela
Sardu, Claudia
Carpiniello, Bernardo
Dell'Osso, Liliana
Mariotti, Stefano
The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
title The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
title_full The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
title_fullStr The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
title_full_unstemmed The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
title_short The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
title_sort link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516779/
https://www.ncbi.nlm.nih.gov/pubmed/15317653
http://dx.doi.org/10.1186/1471-244X-4-25
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