Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue

Postnatal mesenchymal stem cells have the capacity to differentiate into multiple cell lineages. This study explored the possibility of dental pulp stem cells (DPSCs) for potential application in tendon tissue engineering. The expression of tendon-related markers such as scleraxis, tenascin-C, tenom...

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Autores principales: Chen, Yu-Ying, He, Sheng-Teng, Yan, Fu-Hua, Zhou, Peng-Fei, Luo, Kai, Zhang, Yan-Ding, Xiao, Yin, Lin, Min-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168414/
https://www.ncbi.nlm.nih.gov/pubmed/27811845
http://dx.doi.org/10.1038/ijos.2016.33
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author Chen, Yu-Ying
He, Sheng-Teng
Yan, Fu-Hua
Zhou, Peng-Fei
Luo, Kai
Zhang, Yan-Ding
Xiao, Yin
Lin, Min-Kui
author_facet Chen, Yu-Ying
He, Sheng-Teng
Yan, Fu-Hua
Zhou, Peng-Fei
Luo, Kai
Zhang, Yan-Ding
Xiao, Yin
Lin, Min-Kui
author_sort Chen, Yu-Ying
collection PubMed
description Postnatal mesenchymal stem cells have the capacity to differentiate into multiple cell lineages. This study explored the possibility of dental pulp stem cells (DPSCs) for potential application in tendon tissue engineering. The expression of tendon-related markers such as scleraxis, tenascin-C, tenomodulin, eye absent homologue 2, collagens I and VI was detected in dental pulp tissue. Interestingly, under mechanical stimulation, these tendon-related markers were significantly enhanced when DPSCs were seeded in aligned polyglycolic acid (PGA) fibre scaffolds. Furthermore, mature tendon-like tissue was formed after transplantation of DPSC-PGA constructs under mechanical loading conditions in a mouse model. This study demonstrates that DPSCs could be a potential stem cell source for tissue engineering of tendon-like tissue.
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spelling pubmed-51684142016-12-21 Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue Chen, Yu-Ying He, Sheng-Teng Yan, Fu-Hua Zhou, Peng-Fei Luo, Kai Zhang, Yan-Ding Xiao, Yin Lin, Min-Kui Int J Oral Sci Original Article Postnatal mesenchymal stem cells have the capacity to differentiate into multiple cell lineages. This study explored the possibility of dental pulp stem cells (DPSCs) for potential application in tendon tissue engineering. The expression of tendon-related markers such as scleraxis, tenascin-C, tenomodulin, eye absent homologue 2, collagens I and VI was detected in dental pulp tissue. Interestingly, under mechanical stimulation, these tendon-related markers were significantly enhanced when DPSCs were seeded in aligned polyglycolic acid (PGA) fibre scaffolds. Furthermore, mature tendon-like tissue was formed after transplantation of DPSC-PGA constructs under mechanical loading conditions in a mouse model. This study demonstrates that DPSCs could be a potential stem cell source for tissue engineering of tendon-like tissue. Nature Publishing Group 2016-12 2016-11-04 /pmc/articles/PMC5168414/ /pubmed/27811845 http://dx.doi.org/10.1038/ijos.2016.33 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
Chen, Yu-Ying
He, Sheng-Teng
Yan, Fu-Hua
Zhou, Peng-Fei
Luo, Kai
Zhang, Yan-Ding
Xiao, Yin
Lin, Min-Kui
Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
title Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
title_full Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
title_fullStr Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
title_full_unstemmed Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
title_short Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
title_sort dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168414/
https://www.ncbi.nlm.nih.gov/pubmed/27811845
http://dx.doi.org/10.1038/ijos.2016.33
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