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Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation
Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168420/ https://www.ncbi.nlm.nih.gov/pubmed/27982023 http://dx.doi.org/10.1038/ijos.2016.45 |
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author | He, Xin-Yu Sun, Ke Xu, Ruo-Shi Tan, Jia-Li Pi, Cai-Xia Wan, Mian Peng, Yi-Ran Ye, Ling Zheng, Li-Wei Zhou, Xue-Dong |
author_facet | He, Xin-Yu Sun, Ke Xu, Ruo-Shi Tan, Jia-Li Pi, Cai-Xia Wan, Mian Peng, Yi-Ran Ye, Ling Zheng, Li-Wei Zhou, Xue-Dong |
author_sort | He, Xin-Yu |
collection | PubMed |
description | Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear. In this study, we investigated the reassociation of tooth germ cells suspension from different morphological stages during tooth development and the phosphorylation of Smad2/3 in this process. Four tooth morphological stages were designed in this study. The results showed that tooth germ cells formed odontogenic tissue at embryonic day (E) 14.5, which is referred to as the cap stage, and they formed tooth-like structures at E16.5, which is referred to as the early bell stage, and E18.5, which is referred to as the late bell stage. Moreover, the transforming growth factor-β signalling pathway might play a role in this process. |
format | Online Article Text |
id | pubmed-5168420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51684202016-12-21 Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation He, Xin-Yu Sun, Ke Xu, Ruo-Shi Tan, Jia-Li Pi, Cai-Xia Wan, Mian Peng, Yi-Ran Ye, Ling Zheng, Li-Wei Zhou, Xue-Dong Int J Oral Sci Original Article Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear. In this study, we investigated the reassociation of tooth germ cells suspension from different morphological stages during tooth development and the phosphorylation of Smad2/3 in this process. Four tooth morphological stages were designed in this study. The results showed that tooth germ cells formed odontogenic tissue at embryonic day (E) 14.5, which is referred to as the cap stage, and they formed tooth-like structures at E16.5, which is referred to as the early bell stage, and E18.5, which is referred to as the late bell stage. Moreover, the transforming growth factor-β signalling pathway might play a role in this process. Nature Publishing Group 2016-12 2016-12-16 /pmc/articles/PMC5168420/ /pubmed/27982023 http://dx.doi.org/10.1038/ijos.2016.45 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article He, Xin-Yu Sun, Ke Xu, Ruo-Shi Tan, Jia-Li Pi, Cai-Xia Wan, Mian Peng, Yi-Ran Ye, Ling Zheng, Li-Wei Zhou, Xue-Dong Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
title | Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
title_full | Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
title_fullStr | Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
title_full_unstemmed | Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
title_short | Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
title_sort | spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168420/ https://www.ncbi.nlm.nih.gov/pubmed/27982023 http://dx.doi.org/10.1038/ijos.2016.45 |
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