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How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?

Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and target...

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Autores principales: Khawar, Muhammad Babar, Azam, Fareeha, Sheikh, Nadeem, Abdul Mujeeb, Khawaja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168458/
https://www.ncbi.nlm.nih.gov/pubmed/28050571
http://dx.doi.org/10.1155/2016/2148129
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author Khawar, Muhammad Babar
Azam, Fareeha
Sheikh, Nadeem
Abdul Mujeeb, Khawaja
author_facet Khawar, Muhammad Babar
Azam, Fareeha
Sheikh, Nadeem
Abdul Mujeeb, Khawaja
author_sort Khawar, Muhammad Babar
collection PubMed
description Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues. It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation. IL-22BP is an inhibitor of IL-22 which has 20–1000x more affinity to bind with IL-22 compared to IL-22R1 that inhibits IL-22 activity. Its level was found to be positively correlated with the severity of liver damage and fibrosis. So, the present review is an effort to reveal the exact mechanism lying in the hepatoprotective activity of IL-22 and some of its future therapeutic implications.
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spelling pubmed-51684582017-01-03 How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? Khawar, Muhammad Babar Azam, Fareeha Sheikh, Nadeem Abdul Mujeeb, Khawaja J Immunol Res Review Article Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues. It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation. IL-22BP is an inhibitor of IL-22 which has 20–1000x more affinity to bind with IL-22 compared to IL-22R1 that inhibits IL-22 activity. Its level was found to be positively correlated with the severity of liver damage and fibrosis. So, the present review is an effort to reveal the exact mechanism lying in the hepatoprotective activity of IL-22 and some of its future therapeutic implications. Hindawi Publishing Corporation 2016 2016-12-06 /pmc/articles/PMC5168458/ /pubmed/28050571 http://dx.doi.org/10.1155/2016/2148129 Text en Copyright © 2016 Muhammad Babar Khawar et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khawar, Muhammad Babar
Azam, Fareeha
Sheikh, Nadeem
Abdul Mujeeb, Khawaja
How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
title How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
title_full How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
title_fullStr How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
title_full_unstemmed How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
title_short How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
title_sort how does interleukin-22 mediate liver regeneration and prevent injury and fibrosis?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168458/
https://www.ncbi.nlm.nih.gov/pubmed/28050571
http://dx.doi.org/10.1155/2016/2148129
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