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Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials

OBJECTIVES: This systematic review aimed to assess the clinical evidence supporting the use of herbal medicines (HMs) for the treatment of otitis media with effusion (OME). DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE, EMBASE, Cochrane Library, AMED, CINAHL and three trial regi...

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Autores principales: Son, Mi Ju, Choi, Songie, Kim, Young-Eun, Kim, Yun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168523/
https://www.ncbi.nlm.nih.gov/pubmed/27884841
http://dx.doi.org/10.1136/bmjopen-2016-011250
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author Son, Mi Ju
Choi, Songie
Kim, Young-Eun
Kim, Yun Hee
author_facet Son, Mi Ju
Choi, Songie
Kim, Young-Eun
Kim, Yun Hee
author_sort Son, Mi Ju
collection PubMed
description OBJECTIVES: This systematic review aimed to assess the clinical evidence supporting the use of herbal medicines (HMs) for the treatment of otitis media with effusion (OME). DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE, EMBASE, Cochrane Library, AMED, CINAHL and three trial registries were searched up to January 2015. We also searched five Korean medical databases (KoreaMed, RISS, OASIS, DBPIA and KISS) and three Chinese databases (CNKI, Wanfang and VIP). STUDY ELIGIBILITY CRITERIA: This study included randomised clinical trials that reported the effects of HM for OME. The primary outcome was the complete resolution of OME at 2 or 3 months post randomisation. Secondary outcomes included the partial or complete resolution at all possible time points and hearing test. Three authors independently screened the titles and abstracts, selected studies and extracted the data relating to trial quality, characteristics and results. RESULTS: A total of 2141 potentially relevant studies were identified, of which 17 randomised clinical trials met our inclusion criteria. Most were evaluated as having a high or unclear risk of bias. Tongqiao tablets, Tongqiao huoxue decoctions and Tsumura-Saireito were associated with a lower complete or partial resolution rate when compared with conventional medicines (CMs) (p=0.02, p=0.0001, and p=0.04, respectively), and similar outcomes were observed with Huanglong tonger pills, Erzhang decoctions and Shenling baizhu powder when combined with CM versus CM alone (p<0.00001, p=0.02, and p=0.05, respectively). Tongqiao huoxue decoction plus CM appeared to be more effective than CM in terms of improving the pure tone threshold levels (p=0.0007). Tsumura-Saireito was found to affect the proportion of patients with normalised tympanometry (p=0.03). CONCLUSIONS: Despite some indications of potential symptom improvement, the evidence regarding the effectiveness and efficacy of HMs for OME is of poor quality and therefore inconclusive. PROTOCOL REGISTRATION NUMBER: CRD42013005430.
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spelling pubmed-51685232016-12-22 Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials Son, Mi Ju Choi, Songie Kim, Young-Eun Kim, Yun Hee BMJ Open Ear, Nose and Throat/Otolaryngology OBJECTIVES: This systematic review aimed to assess the clinical evidence supporting the use of herbal medicines (HMs) for the treatment of otitis media with effusion (OME). DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE, EMBASE, Cochrane Library, AMED, CINAHL and three trial registries were searched up to January 2015. We also searched five Korean medical databases (KoreaMed, RISS, OASIS, DBPIA and KISS) and three Chinese databases (CNKI, Wanfang and VIP). STUDY ELIGIBILITY CRITERIA: This study included randomised clinical trials that reported the effects of HM for OME. The primary outcome was the complete resolution of OME at 2 or 3 months post randomisation. Secondary outcomes included the partial or complete resolution at all possible time points and hearing test. Three authors independently screened the titles and abstracts, selected studies and extracted the data relating to trial quality, characteristics and results. RESULTS: A total of 2141 potentially relevant studies were identified, of which 17 randomised clinical trials met our inclusion criteria. Most were evaluated as having a high or unclear risk of bias. Tongqiao tablets, Tongqiao huoxue decoctions and Tsumura-Saireito were associated with a lower complete or partial resolution rate when compared with conventional medicines (CMs) (p=0.02, p=0.0001, and p=0.04, respectively), and similar outcomes were observed with Huanglong tonger pills, Erzhang decoctions and Shenling baizhu powder when combined with CM versus CM alone (p<0.00001, p=0.02, and p=0.05, respectively). Tongqiao huoxue decoction plus CM appeared to be more effective than CM in terms of improving the pure tone threshold levels (p=0.0007). Tsumura-Saireito was found to affect the proportion of patients with normalised tympanometry (p=0.03). CONCLUSIONS: Despite some indications of potential symptom improvement, the evidence regarding the effectiveness and efficacy of HMs for OME is of poor quality and therefore inconclusive. PROTOCOL REGISTRATION NUMBER: CRD42013005430. BMJ Publishing Group 2016-11-24 /pmc/articles/PMC5168523/ /pubmed/27884841 http://dx.doi.org/10.1136/bmjopen-2016-011250 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Ear, Nose and Throat/Otolaryngology
Son, Mi Ju
Choi, Songie
Kim, Young-Eun
Kim, Yun Hee
Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
title Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
title_full Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
title_fullStr Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
title_full_unstemmed Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
title_short Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
title_sort herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials
topic Ear, Nose and Throat/Otolaryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168523/
https://www.ncbi.nlm.nih.gov/pubmed/27884841
http://dx.doi.org/10.1136/bmjopen-2016-011250
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