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Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study

OBJECTIVES: To investigate an association between ideal cardiovascular health metrics (CVH) and the risk of developing end-stage renal disease (ESRD). SETTING: Community of Kailuan in Tangshan/China. PARTICIPANTS: We examined in a community-based longitudinal cohort study 91 443 participants without...

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Autores principales: Han, Quan Le, Wu, Shou Ling, Liu, Xiao Xue, An, Sha Sha, Wu, Yun Tao, Gao, Jing Sheng, Chen, Shuo Hua, Liu, Xiao Kun, Zhang, Qi, Mao, Rui Ying, Shang, Xiao Ming, Jonas, Jost B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168547/
https://www.ncbi.nlm.nih.gov/pubmed/27899399
http://dx.doi.org/10.1136/bmjopen-2016-012486
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author Han, Quan Le
Wu, Shou Ling
Liu, Xiao Xue
An, Sha Sha
Wu, Yun Tao
Gao, Jing Sheng
Chen, Shuo Hua
Liu, Xiao Kun
Zhang, Qi
Mao, Rui Ying
Shang, Xiao Ming
Jonas, Jost B
author_facet Han, Quan Le
Wu, Shou Ling
Liu, Xiao Xue
An, Sha Sha
Wu, Yun Tao
Gao, Jing Sheng
Chen, Shuo Hua
Liu, Xiao Kun
Zhang, Qi
Mao, Rui Ying
Shang, Xiao Ming
Jonas, Jost B
author_sort Han, Quan Le
collection PubMed
description OBJECTIVES: To investigate an association between ideal cardiovascular health metrics (CVH) and the risk of developing end-stage renal disease (ESRD). SETTING: Community of Kailuan in Tangshan/China. PARTICIPANTS: We examined in a community-based longitudinal cohort study 91 443 participants without history of stroke or myocardial infarction at baseline in 2006–2007, with a glomerular filtration rate (GFR) ≥15 mL/min at baseline, and who participated in at least 1 of 3 follow-up examinations in 2008–2009, 2010–2011 and 2012–2013. INTERVENTIONS: CVH was measured by 7 key health factors (smoking, body mass index, physical activity, healthy dietary score, total cholesterol blood concentration, blood pressure, fasting blood glucose) each of which ranged between ‘ideal’ (2) and ‘poor’ (0). With a maximal CVH score of 14, the study participants were divided into categories of <5, 5–9 and 10–14 points. PRIMARY AND SECONDARY OUTCOME MEASURES: CHV, incidence of ESRD. RESULTS: Incidence of ESRD ranged from 7.06‰ in the lowest CVH category to 2.34‰ in the highest CVH category. After adjusting for age, sex, educational level, income, alcohol consumption and GFR, the lowest CVH category as compared with the highest CVH category had a significantly higher risk of incident ESRD (adjusted HR 2.87; 95% CI 1.53 to 5.39). For every decrease in group number of the cum-CVH score, the risk of ESRD increased by 20% (HR 1.20; 95% CI 1.13 to 1.28). The effect was consistent across sex and all age groups. CONCLUSIONS: A low CVH score significantly increased the risk of incident ESRD. Risk factors for cardiovascular events may also be associated with an increased risk for kidney failure.
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spelling pubmed-51685472016-12-22 Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study Han, Quan Le Wu, Shou Ling Liu, Xiao Xue An, Sha Sha Wu, Yun Tao Gao, Jing Sheng Chen, Shuo Hua Liu, Xiao Kun Zhang, Qi Mao, Rui Ying Shang, Xiao Ming Jonas, Jost B BMJ Open Renal Medicine OBJECTIVES: To investigate an association between ideal cardiovascular health metrics (CVH) and the risk of developing end-stage renal disease (ESRD). SETTING: Community of Kailuan in Tangshan/China. PARTICIPANTS: We examined in a community-based longitudinal cohort study 91 443 participants without history of stroke or myocardial infarction at baseline in 2006–2007, with a glomerular filtration rate (GFR) ≥15 mL/min at baseline, and who participated in at least 1 of 3 follow-up examinations in 2008–2009, 2010–2011 and 2012–2013. INTERVENTIONS: CVH was measured by 7 key health factors (smoking, body mass index, physical activity, healthy dietary score, total cholesterol blood concentration, blood pressure, fasting blood glucose) each of which ranged between ‘ideal’ (2) and ‘poor’ (0). With a maximal CVH score of 14, the study participants were divided into categories of <5, 5–9 and 10–14 points. PRIMARY AND SECONDARY OUTCOME MEASURES: CHV, incidence of ESRD. RESULTS: Incidence of ESRD ranged from 7.06‰ in the lowest CVH category to 2.34‰ in the highest CVH category. After adjusting for age, sex, educational level, income, alcohol consumption and GFR, the lowest CVH category as compared with the highest CVH category had a significantly higher risk of incident ESRD (adjusted HR 2.87; 95% CI 1.53 to 5.39). For every decrease in group number of the cum-CVH score, the risk of ESRD increased by 20% (HR 1.20; 95% CI 1.13 to 1.28). The effect was consistent across sex and all age groups. CONCLUSIONS: A low CVH score significantly increased the risk of incident ESRD. Risk factors for cardiovascular events may also be associated with an increased risk for kidney failure. BMJ Publishing Group 2016-11-29 /pmc/articles/PMC5168547/ /pubmed/27899399 http://dx.doi.org/10.1136/bmjopen-2016-012486 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Renal Medicine
Han, Quan Le
Wu, Shou Ling
Liu, Xiao Xue
An, Sha Sha
Wu, Yun Tao
Gao, Jing Sheng
Chen, Shuo Hua
Liu, Xiao Kun
Zhang, Qi
Mao, Rui Ying
Shang, Xiao Ming
Jonas, Jost B
Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
title Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
title_full Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
title_fullStr Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
title_full_unstemmed Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
title_short Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
title_sort ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the kailuan study
topic Renal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168547/
https://www.ncbi.nlm.nih.gov/pubmed/27899399
http://dx.doi.org/10.1136/bmjopen-2016-012486
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