Cargando…

Can commonly prescribed drugs be repurposed for the prevention or treatment of Alzheimer's and other neurodegenerative diseases? Protocol for an observational cohort study in the UK Clinical Practice Research Datalink

INTRODUCTION: Current treatments for Alzheimer's and other neurodegenerative diseases have only limited effectiveness meaning that there is an urgent need for new medications that could influence disease incidence and progression. We will investigate the potential of a selection of commonly pre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walker, Venexia M, Davies, Neil M, Jones, Tim, Kehoe, Patrick G, Martin, Richard M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Pharmacology and Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168636/ https://www.ncbi.nlm.nih.gov/pubmed/27965247 http://dx.doi.org/10.1136/bmjopen-2016-012044

Ejemplares similares

Pharmacoepidemiology in pregnancy: analysis protocol for an observational cohort study in the UK Clinical Practice Research Datalink
por: Barry, Ciarrah-Jane, et al.
Publicado: (2022)

Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study
por: Walker, Venexia M, et al.
Publicado: (2019)

What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink
por: Walker, Venexia M., et al.
Publicado: (2018)

Understanding doctors’ emergency department antibiotic prescribing decisions in children with respiratory symptoms in the UK: a qualitative study
por: Hampton, Thomas, et al.
Publicado: (2021)

Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders
por: Shah, Sweta, et al.
Publicado: (2021)

Evaluation of the incremental cost to the National Health Service of prescribing analogue insulin
por: Holden, Sarah E, et al.
Publicado: (2011)

Potentially inappropriate prescribing and its association with health outcomes in middle-aged people: a prospective cohort study in Ireland
por: Moriarty, Frank, et al.
Publicado: (2017)

Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study
por: O Riordan, David, et al.
Publicado: (2018)

Trends and interaction of polypharmacy and potentially inappropriate prescribing in primary care over 15 years in Ireland: a repeated cross-sectional study
por: Moriarty, Frank, et al.
Publicado: (2015)

Behaviour change interventions to promote prescribing of generic drugs: a rapid evidence synthesis and systematic review
por: Moe-Byrne, Thirimon, et al.
Publicado: (2014)

Comparative, cross-sectional study of the format, content and timing of medication safety letters issued in Canada, the USA and the UK
por: Bjerre, Lise M, et al.
Publicado: (2018)

Trends of prescribing antimicrobial drugs for urinary tract infections in primary care in the Netherlands: a population-based cohort study
por: Mulder, Marlies, et al.
Publicado: (2019)

Proton pump inhibitor utilisation and potentially inappropriate prescribing analysis: insights from a single-centred retrospective study
por: Liu, Yujuan, et al.
Publicado: (2020)

Chinese physicians’ attitudes toward eco-directed sustainable prescribing from the perspective of ecopharmacovigilance: a cross-sectional study
por: Wang, Jun, et al.
Publicado: (2020)

Association of co-prescribing of opioid and benzodiazepine substitutes with incident falls and fractures among older adults: a cohort study
por: Shah, Rahul, et al.
Publicado: (2021)

What were the impacts of the Committee on Safety of Medicines warning and publication of the NICE guidelines on trends in child and adolescent antidepressant prescribing in primary care? A population based study
por: Tiffin, Paul A, et al.
Publicado: (2019)

Benzodiazepine prescribing in children under 15 years of age receiving free medical care on the General Medical Services scheme in Ireland
por: O'Sullivan, K, et al.
Publicado: (2015)

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities
por: Walker, Venexia M, et al.
Publicado: (2017)

Bad apples or spoiled barrels? Multilevel modelling analysis of variation in high-risk prescribing in Scotland between general practitioners and between the practices they work in
por: Guthrie, Bruce, et al.
Publicado: (2015)

Cohort profile: the Finnish Medication and Alzheimer's disease (MEDALZ) study
por: Tolppanen, Anna-Maija, et al.
Publicado: (2016)

Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways
por: Soranzo, Nicole, et al.
Publicado: (2010)

Trends in clinical development timeframes for antiviral drugs launched in the UK, 1981–2014: a retrospective observational study
por: Ward, Derek J, et al.
Publicado: (2015)

Applying quality improvement methods to address gaps in medicines reconciliation at transfers of care from an acute UK hospital
por: Marvin, Vanessa, et al.
Publicado: (2016)

Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial
por: Hemilä, Harri, et al.
Publicado: (2020)

Meta-analysis: the effects of smoking on the disposition of two commonly used antipsychotic agents, olanzapine and clozapine
por: Tsuda, Yoshiyuki, et al.
Publicado: (2014)

How innovative are new drugs launched in the UK? A retrospective study of new drugs listed in the British National Formulary (BNF) 2001–2012
por: Ward, Derek J, et al.
Publicado: (2014)

GPs' perspectives on prescribing for older people in primary care: a qualitative study
por: Riordan, David O., et al.
Publicado: (2017)

Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study
por: Sadowski, Alexander, et al.
Publicado: (2013)

Relationship between primary school healthy eating and physical activity promoting environments and children’s dietary intake, physical activity and weight status: a longitudinal study in the West Midlands, UK
por: Garden, Elizabeth Mairenn, et al.
Publicado: (2020)

Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders
por: Chen, Qian, et al.
Publicado: (2021)

Neuroinflammation as a Common Feature of Neurodegenerative Disorders
por: Guzman-Martinez, Leonardo, et al.
Publicado: (2019)

Examining variations in prescribing safety in UK general practice: cross sectional study using the Clinical Practice Research Datalink
por: Stocks, S Jill, et al.
Publicado: (2015)

Brain connectivity-guided, Optimised theta burst transcranial magnetic stimulation to improve Central Pain Modulation in knee Osteoarthritis Pain (BoostCPM): protocol of a pilot randomised clinical trial in a secondary care setting in the UK
por: Drabek, Marianne, et al.
Publicado: (2023)

Obesity independently predicts responders to biphasic insulin 50/50 (Humalog Mix50 and Insuman Comb 50) following conversion from other insulin regimens: a retrospective cohort study
por: Mamza, J, et al.
Publicado: (2014)

Association between cumulative anticholinergic burden and falls and fractures in patients with overactive bladder: US-based retrospective cohort study
por: Szabo, Shelagh M, et al.
Publicado: (2019)

Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy
por: Michaels, Samantha A., et al.
Publicado: (2022)

Evaluating the safety of mental health-related prescribing in UK primary care: a cross-sectional study using the Clinical Practice Research Datalink (CPRD)
por: Khawagi, Wael Y, et al.
Publicado: (2022)

Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions
por: Osanlou, Rostam, et al.
Publicado: (2022)

Process mapping evaluation of medication reconciliation in academic teaching hospitals: a critical step in quality improvement
por: Holbrook, Anne, et al.
Publicado: (2016)

How are drug regimen changes during hospitalisation handled after discharge: a cohort study
por: Viktil, Kirsten K, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_e6utpft1gbk5jdtmoptbli930m