Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis

[Image: see text] Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C–C bonds are formed and transition metals are not required to run these sequences. The...

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Autores principales: Xuan, Jun, Daniliuc, Constantin G., Studer, Armido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168651/
https://www.ncbi.nlm.nih.gov/pubmed/27978670
http://dx.doi.org/10.1021/acs.orglett.6b03267
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author Xuan, Jun
Daniliuc, Constantin G.
Studer, Armido
author_facet Xuan, Jun
Daniliuc, Constantin G.
Studer, Armido
author_sort Xuan, Jun
collection PubMed
description [Image: see text] Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C–C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable.
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spelling pubmed-51686512016-12-21 Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis Xuan, Jun Daniliuc, Constantin G. Studer, Armido Org Lett [Image: see text] Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C–C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable. American Chemical Society 2016-11-29 2016-12-16 /pmc/articles/PMC5168651/ /pubmed/27978670 http://dx.doi.org/10.1021/acs.orglett.6b03267 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Xuan, Jun
Daniliuc, Constantin G.
Studer, Armido
Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
title Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
title_full Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
title_fullStr Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
title_full_unstemmed Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
title_short Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
title_sort construction of polycyclic γ-lactams and related heterocycles via electron catalysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168651/
https://www.ncbi.nlm.nih.gov/pubmed/27978670
http://dx.doi.org/10.1021/acs.orglett.6b03267
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