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Genetic and Epigenetic Alterations in Bladder Cancer
Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingl...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Continence Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169086/ https://www.ncbi.nlm.nih.gov/pubmed/27915480 http://dx.doi.org/10.5213/inj.1632752.376 |
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author | Li, Hong-Tao Duymich, Christopher E. Weisenberger, Daniel J. Liang, Gangning |
author_facet | Li, Hong-Tao Duymich, Christopher E. Weisenberger, Daniel J. Liang, Gangning |
author_sort | Li, Hong-Tao |
collection | PubMed |
description | Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct genetic and epigenetic alteration patterns in bladder cancer, even between the different stages and grades of disease. In addition, genetic and epigenetic alterations have been demonstrated to play important roles during bladder tumorigenesis. This review will focus on bladder cancer-associated genomic and epigenomic alterations, which are common in bladder cancer and provide potential diagnostic markers and therapeutic targets for bladder cancer treatment. |
format | Online Article Text |
id | pubmed-5169086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Continence Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-51690862016-12-20 Genetic and Epigenetic Alterations in Bladder Cancer Li, Hong-Tao Duymich, Christopher E. Weisenberger, Daniel J. Liang, Gangning Int Neurourol J Review Article Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct genetic and epigenetic alteration patterns in bladder cancer, even between the different stages and grades of disease. In addition, genetic and epigenetic alterations have been demonstrated to play important roles during bladder tumorigenesis. This review will focus on bladder cancer-associated genomic and epigenomic alterations, which are common in bladder cancer and provide potential diagnostic markers and therapeutic targets for bladder cancer treatment. Korean Continence Society 2016-11 2016-11-22 /pmc/articles/PMC5169086/ /pubmed/27915480 http://dx.doi.org/10.5213/inj.1632752.376 Text en Copyright © 2016 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Hong-Tao Duymich, Christopher E. Weisenberger, Daniel J. Liang, Gangning Genetic and Epigenetic Alterations in Bladder Cancer |
title | Genetic and Epigenetic Alterations in Bladder Cancer |
title_full | Genetic and Epigenetic Alterations in Bladder Cancer |
title_fullStr | Genetic and Epigenetic Alterations in Bladder Cancer |
title_full_unstemmed | Genetic and Epigenetic Alterations in Bladder Cancer |
title_short | Genetic and Epigenetic Alterations in Bladder Cancer |
title_sort | genetic and epigenetic alterations in bladder cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169086/ https://www.ncbi.nlm.nih.gov/pubmed/27915480 http://dx.doi.org/10.5213/inj.1632752.376 |
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