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Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008
BACKGROUND. Although human immunodeficiency virus (HIV) infection is an established risk factor for several bacterial infections, the association between HIV infection and meningococcal disease remains unclear. METHODS. Expanded chart reviews were completed on persons with meningococcal disease and...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170493/ https://www.ncbi.nlm.nih.gov/pubmed/28018927 http://dx.doi.org/10.1093/ofid/ofw226 |
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author | Harris, Christine M. Wu, Henry M. Li, Jianmin Hall, H. Irene Lee, Adria Zell, Elizabeth Harrison, Lee H. Petit, Susan Farley, Monica M. Lynfield, Ruth Miller, Lisa Nichols, Megin Reingold, Arthur Schaffner, William Thomas, Ann MacNeil, Jessica R. Clark, Thomas A. Cohn, Amanda C. |
author_facet | Harris, Christine M. Wu, Henry M. Li, Jianmin Hall, H. Irene Lee, Adria Zell, Elizabeth Harrison, Lee H. Petit, Susan Farley, Monica M. Lynfield, Ruth Miller, Lisa Nichols, Megin Reingold, Arthur Schaffner, William Thomas, Ann MacNeil, Jessica R. Clark, Thomas A. Cohn, Amanda C. |
author_sort | Harris, Christine M. |
collection | PubMed |
description | BACKGROUND. Although human immunodeficiency virus (HIV) infection is an established risk factor for several bacterial infections, the association between HIV infection and meningococcal disease remains unclear. METHODS. Expanded chart reviews were completed on persons with meningococcal disease and HIV infection reported from 2000 through 2008 from 9 US sites participating in an active population-based surveillance system for meningococcal disease. The incidence of meningococcal disease among patients meeting Centers for Disease Control and Prevention acquired immune deficiency syndrome (AIDS) surveillance criteria was estimated using data from the National HIV Surveillance System for the participating sites. RESULTS. Thirty-three cases of meningococcal disease in individuals with HIV infection were reported from participating sites, representing 2.0% of all reported meningococcal disease cases. Most (75.8%) persons with HIV infection were adult males aged 25 to 64 years old. Among all meningococcal disease cases aged 25 to 64 years old, case fatality ratios were similar among HIV-infected and HIV-uninfected persons (13.3% vs 10.6%; P = .6). The cumulative, mean incidence of meningococcal disease among patients aged 25 to 64 years old with HIV infection ever classified as AIDS was 3.5 cases per 100000 person years (95% confidence interval [CI], 2.1–5.6), compared with 0.3 cases per 100000 person years (95% CI, 0.3–0.3) for persons of the same age group not reported to have AIDS (relative risk = 12.9; 95% CI, 7.9–20.9). CONCLUSIONS. Individuals with HIV infection meeting the AIDS surveillance case definition have a higher incidence of meningococcal disease compared with the general adult population. |
format | Online Article Text |
id | pubmed-5170493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51704932016-12-23 Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 Harris, Christine M. Wu, Henry M. Li, Jianmin Hall, H. Irene Lee, Adria Zell, Elizabeth Harrison, Lee H. Petit, Susan Farley, Monica M. Lynfield, Ruth Miller, Lisa Nichols, Megin Reingold, Arthur Schaffner, William Thomas, Ann MacNeil, Jessica R. Clark, Thomas A. Cohn, Amanda C. Open Forum Infect Dis Major Article BACKGROUND. Although human immunodeficiency virus (HIV) infection is an established risk factor for several bacterial infections, the association between HIV infection and meningococcal disease remains unclear. METHODS. Expanded chart reviews were completed on persons with meningococcal disease and HIV infection reported from 2000 through 2008 from 9 US sites participating in an active population-based surveillance system for meningococcal disease. The incidence of meningococcal disease among patients meeting Centers for Disease Control and Prevention acquired immune deficiency syndrome (AIDS) surveillance criteria was estimated using data from the National HIV Surveillance System for the participating sites. RESULTS. Thirty-three cases of meningococcal disease in individuals with HIV infection were reported from participating sites, representing 2.0% of all reported meningococcal disease cases. Most (75.8%) persons with HIV infection were adult males aged 25 to 64 years old. Among all meningococcal disease cases aged 25 to 64 years old, case fatality ratios were similar among HIV-infected and HIV-uninfected persons (13.3% vs 10.6%; P = .6). The cumulative, mean incidence of meningococcal disease among patients aged 25 to 64 years old with HIV infection ever classified as AIDS was 3.5 cases per 100000 person years (95% confidence interval [CI], 2.1–5.6), compared with 0.3 cases per 100000 person years (95% CI, 0.3–0.3) for persons of the same age group not reported to have AIDS (relative risk = 12.9; 95% CI, 7.9–20.9). CONCLUSIONS. Individuals with HIV infection meeting the AIDS surveillance case definition have a higher incidence of meningococcal disease compared with the general adult population. Oxford University Press 2016-12-20 /pmc/articles/PMC5170493/ /pubmed/28018927 http://dx.doi.org/10.1093/ofid/ofw226 Text en Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US. |
spellingShingle | Major Article Harris, Christine M. Wu, Henry M. Li, Jianmin Hall, H. Irene Lee, Adria Zell, Elizabeth Harrison, Lee H. Petit, Susan Farley, Monica M. Lynfield, Ruth Miller, Lisa Nichols, Megin Reingold, Arthur Schaffner, William Thomas, Ann MacNeil, Jessica R. Clark, Thomas A. Cohn, Amanda C. Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 |
title | Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 |
title_full | Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 |
title_fullStr | Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 |
title_full_unstemmed | Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 |
title_short | Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000–2008 |
title_sort | meningococcal disease in patients with human immunodeficiency virus infection: a review of cases reported through active surveillance in the united states, 2000–2008 |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170493/ https://www.ncbi.nlm.nih.gov/pubmed/28018927 http://dx.doi.org/10.1093/ofid/ofw226 |
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