Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation

Recent work has revealed a central role for neddylation (the conjugation of a Nedd8 moiety to Cullin proteins) in the fine-tuning of the NF-κB response (via Cullin-1). In the present study, we investigated the contribution of Cullin-1 neddylation and NF-κB signaling to mucosal inflammatory responses...

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Detalles Bibliográficos
Autores principales: Ehrentraut, Stefan F., Curtis, Valerie F., Wang, Ruth X., Saeedi, Bejan J., Ehrentraut, Heidi, Onyiah, Joseph C., Kelly, Caleb J., Campbell, Eric L., Glover, Louise E., Kominsky, Douglas J., Colgan, Sean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170552/
https://www.ncbi.nlm.nih.gov/pubmed/27682585
http://dx.doi.org/10.1091/mbc.E16-05-0273

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