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Arl13b regulates Shh signaling from both inside and outside the cilium

The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling. Missense mutations in ARL13B can cause the ciliopathy Joubert syndrome (JS), and the mouse null allele is embryonic lethal. We used mouse embryonic fibroblasts as a system to determine the eff...

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Detalles Bibliográficos
Autores principales:	Mariani, Laura E., Bijlsma, Maarten F., Ivanova, Anna I., Suciu, Sarah K., Kahn, Richard A., Caspary, Tamara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170560/ https://www.ncbi.nlm.nih.gov/pubmed/27682584 http://dx.doi.org/10.1091/mbc.E16-03-0189

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