Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

According to the three-dimensional (3D) complex structure of (hIL-6⋅hIL-6R⋅gp 130)(2) and the binding orientation of hIL-6, three compounds with high affinity to hIL-6R and bioactivity to block hIL-6 in vitro were screened theoretically from the chemical databases, including 3D-Available Chemicals D...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Qiao, Chunxia, Xiao, He, Lin, Zhou, Li, Yan, Zhang, Jiyan, Shen, Beifen, Fu, Tinghuan, Feng, Jiannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170619/
https://www.ncbi.nlm.nih.gov/pubmed/28008232
http://dx.doi.org/10.2147/DDDT.S118457

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