Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes

Dysregulated hepatic cholesterol homeostasis with free cholesterol accumulation in the liver is relevant to the pathogenesis of nonalcoholic steatohepatitis, contributing to the chronicity of liver toxicity. Here we examined the effect of free cholesterol accumulation on the morphology and biochemic...

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Detalles Bibliográficos
Autores principales: Makino, Asami, Hullin-Matsuda, Françoise, Murate, Motohide, Abe, Mitsuhiro, Tomishige, Nario, Fukuda, Mitsunori, Yamashita, Shizuya, Fujimoto, Toyoshi, Vidal, Hubert, Lagarde, Michel, Delton, Isabelle, Kobayashi, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170862/
https://www.ncbi.nlm.nih.gov/pubmed/27582390
http://dx.doi.org/10.1091/mbc.E15-10-0730

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