TET enzymes: double agents in the transposable element–host genome conflict

The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica a...

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Autores principales: Gerdes, Patricia, Richardson, Sandra R., Faulkner, Geoffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170891/
https://www.ncbi.nlm.nih.gov/pubmed/27993162
http://dx.doi.org/10.1186/s13059-016-1124-8
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author Gerdes, Patricia
Richardson, Sandra R.
Faulkner, Geoffrey J.
author_facet Gerdes, Patricia
Richardson, Sandra R.
Faulkner, Geoffrey J.
author_sort Gerdes, Patricia
collection PubMed
description The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica and colleagues have uncovered a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs), implicating TETs as enhancers in the exaptation and function of retroelement sequences. Furthermore, they have demonstrated that active demethylation of retrotransposons does not correlate with their increased expression in ESCs, calling into question long-held assumptions regarding the importance of DNA demethylation for retrotransposon expression, and revealing novel epigenetic players in retrotransposon control. Please see related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1096-8
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spelling pubmed-51708912016-12-28 TET enzymes: double agents in the transposable element–host genome conflict Gerdes, Patricia Richardson, Sandra R. Faulkner, Geoffrey J. Genome Biol Research Highlight The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica and colleagues have uncovered a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs), implicating TETs as enhancers in the exaptation and function of retroelement sequences. Furthermore, they have demonstrated that active demethylation of retrotransposons does not correlate with their increased expression in ESCs, calling into question long-held assumptions regarding the importance of DNA demethylation for retrotransposon expression, and revealing novel epigenetic players in retrotransposon control. Please see related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1096-8 BioMed Central 2016-12-20 /pmc/articles/PMC5170891/ /pubmed/27993162 http://dx.doi.org/10.1186/s13059-016-1124-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Gerdes, Patricia
Richardson, Sandra R.
Faulkner, Geoffrey J.
TET enzymes: double agents in the transposable element–host genome conflict
title TET enzymes: double agents in the transposable element–host genome conflict
title_full TET enzymes: double agents in the transposable element–host genome conflict
title_fullStr TET enzymes: double agents in the transposable element–host genome conflict
title_full_unstemmed TET enzymes: double agents in the transposable element–host genome conflict
title_short TET enzymes: double agents in the transposable element–host genome conflict
title_sort tet enzymes: double agents in the transposable element–host genome conflict
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170891/
https://www.ncbi.nlm.nih.gov/pubmed/27993162
http://dx.doi.org/10.1186/s13059-016-1124-8
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