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Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans) is a potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in the progression of neurodegenerative diseases. To better understand its function and develop specific compounds that tar...

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Detalles Bibliográficos
Autores principales:	Michels, Helen, Seinstra, Renée I., Uitdehaag, Joost C. M., Koopman, Mandy, van Faassen, Martijn, Martineau, Céline N., Kema, Ido P., Buijsman, Rogier, Nollen, Ellen A. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171515/ https://www.ncbi.nlm.nih.gov/pubmed/27995966 http://dx.doi.org/10.1038/srep39199

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