Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring

Hypertension is a major risk factor for cardiovascular and cerebrovascular disease. Prenatal exposure to lipopolysaccharide (LPS) leads to hypertension in a rat offspring. However, the mechanism is still unclear. This study unraveled epigenetic mechanism for this and explored the protective effects...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Yin, Na, Deng, Youcai, Wei, Yanling, Huang, Yinhu, Pu, Xiaoyun, Li, Li, Zheng, Yingru, Guo, Jianxin, Yu, Jianhua, Li, Xiaohui, Yi, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171640/
https://www.ncbi.nlm.nih.gov/pubmed/27995995
http://dx.doi.org/10.1038/srep39469

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