Cargando…

A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Pancreatic islet transplantation is a promising potential cure for type 1 diabetes (T1D). Islet allografts can survive long term in the liver parenchyma. Here we show that liver NK1.1(+) cells induce allograft tolerance in a T1D mouse model. The tolerogenic effects of NK1.1(+) cells are mediated thr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tripathi, Deepak, Venkatasubramanian, Sambasivan, Cheekatla, Satyanarayana S., Paidipally, Padmaja, Welch, Elwyn, Tvinnereim, Amy R., Vankayalapati, Ramakrishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171644/ https://www.ncbi.nlm.nih.gov/pubmed/27982034 http://dx.doi.org/10.1038/ncomms13896

Ejemplares similares

IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis
por: Venkatasubramanian, Sambasivan, et al.
Publicado: (2016)

c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice
por: Tripathi, Deepak, et al.
Publicado: (2018)

A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of Mycobacterium tuberculosis
por: Venkatasubramanian, Sambasivan, et al.
Publicado: (2015)

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection
por: Cheekatla, Satyanarayana Swamy, et al.
Publicado: (2016)

Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis
por: Tripathi, Deepak, et al.
Publicado: (2018)

IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis
por: Tripathi, Deepak, et al.
Publicado: (2019)

Correction: IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis
por: Tripathi, Deepak, et al.
Publicado: (2021)

HIV-Differentiated Metabolite N-Acetyl-L-Alanine Dysregulates Human Natural Killer Cell Responses to Mycobacterium tuberculosis Infection
por: Yang, Baojun, et al.
Publicado: (2023)

RETRACTED ARTICLE: Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
por: Sivangala Thandi, Ramya, et al.
Publicado: (2020)

Retraction Note: Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
por: Sivangala Thandi, Ramya, et al.
Publicado: (2022)

Metabolites enhance innate resistance to human Mycobacterium tuberculosis infection
por: Tripathi, Deepak, et al.
Publicado: (2022)

IL-17 and IL-22 production in HIV+ individuals with latent and active tuberculosis
por: Devalraju, Kamakshi Prudhula, et al.
Publicado: (2018)

Reduced thyroxine production in young household contacts of tuberculosis patients increases active tuberculosis disease risk
por: Devalraju, Kamakshi Prudhula, et al.
Publicado: (2021)

Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury
por: Melin, Nicolas, et al.
Publicado: (2021)

IL‐10 producing type 2 innate lymphoid cells prolong islet allograft survival
por: Huang, Qingsong, et al.
Publicado: (2020)

iPSC-MSCs and islet allograft tolerance
por: Wang, Tong-Song, et al.
Publicado: (2015)

TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair
por: Natarajan, Chandramohan, et al.
Publicado: (2016)

Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection
por: Moreira, Jôsimar Dornelas, et al.
Publicado: (2022)

Single-Cell Landscape of Mouse Islet Allograft and Syngeneic Graft
por: Chen, Pengfei, et al.
Publicado: (2022)

Dendritic Cells Transduced with Single Immunoglobulin IL-1-Related Receptor Exhibit Immature Properties and Prolong Islet Allograft Survival
por: Xue, Zhicheng, et al.
Publicado: (2017)

HLA-B Matching Prolongs Allograft Survival in Islet Cell Transplantation
por: Lemos, Joana R. N., et al.
Publicado: (2023)

Impact of GAD65 and IA2 autoantibodies on islet allograft survival
por: Lemos, Joana R. N., et al.
Publicado: (2023)

TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-κB-IL6 signaling pathway
por: REN, XINGBIN, et al.
Publicado: (2016)

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
por: Sun, Jinghua, et al.
Publicado: (2012)

Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer
por: Shukla, Nikunj M., et al.
Publicado: (2012)

IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
por: Zenewicz, Lauren A.
Publicado: (2021)

Dual roles of IL-22 at ischemia-reperfusion injury and acute rejection stages of rat allograft liver transplantation
por: Zhang, Yi, et al.
Publicado: (2017)

Pretransplant Immune Parameters Associate With Islet Allograft Outcome: Implications for Transplant Strategy?
por: Kenyon, Norma S., et al.
Publicado: (2009)

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection
por: Vergani, Andrea, et al.
Publicado: (2013)

PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice
por: Ma, Dongxia, et al.
Publicado: (2016)

FasL microgels induce immune acceptance of islet allografts in nonhuman primates
por: Lei, Ji, et al.
Publicado: (2022)

Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production
por: Tang, Anthony C, et al.
Publicado: (2018)

Comparison of human B cell activation by TLR7 and TLR9 agonists
por: Hanten, John A, et al.
Publicado: (2008)

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
por: Cheng, Kui, et al.
Publicado: (2015)

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
por: Frega, Giorgio, et al.
Publicado: (2020)

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization
por: Yoon, Juhan, et al.
Publicado: (2016)

An efficient and scalable synthesis of potent TLR2 agonistic PAM(2)CSK(4)
por: Kaur, Arshpreet, et al.
Publicado: (2018)

P2X7 Gene Polymorphisms and Risk Assessment for Pulmonary Tuberculosis in Asian Indians
por: Sambasivan, Venkatasubramanian, et al.
Publicado: (2010)

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
por: Webster, Kylie E., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ef3s1f8v2nc24229s7cvs3mlmo