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Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism

Altered DNA methylation is common in cancer and often considered an early event in tumorigenesis. However, the sources of heterogeneity of DNA methylation among tumours remain poorly defined. Here we capitalize on the availability of multi-platform data on thousands of human tumours to build integra...

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Detalles Bibliográficos
Autores principales:	Mehrmohamadi, Mahya, Mentch, Lucas K., Clark, Andrew G., Locasale, Jason W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171841/ https://www.ncbi.nlm.nih.gov/pubmed/27966532 http://dx.doi.org/10.1038/ncomms13666

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