NQO1 inhibits proteasome-mediated degradation of HIF-1α

Overexpression of NQO1 is associated with poor prognosis in human cancers including breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-tumorigenic capacities of NQO1 have not been fully elucidated. Here we show a previously undescribed function for NQO1 in sta...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Eun-Taex, Kim, Jung-whan, Kim, Joon Mee, Kim, Soo Jung, Lee, Jae-Seon, Hong, Soon-Sun, Goodwin, Justin, Ruthenborg, Robin J., Jung, Myung Gu, Lee, Hae-June, Lee, Chul-Ho, Park, Eun Sung, Kim, Chulhee, Park, Heon Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171868/
https://www.ncbi.nlm.nih.gov/pubmed/27966538
http://dx.doi.org/10.1038/ncomms13593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171868/
https://www.ncbi.nlm.nih.gov/pubmed/27966538
http://dx.doi.org/10.1038/ncomms13593

Ejemplares similares