Cargando…
NQO1 inhibits proteasome-mediated degradation of HIF-1α
Overexpression of NQO1 is associated with poor prognosis in human cancers including breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-tumorigenic capacities of NQO1 have not been fully elucidated. Here we show a previously undescribed function for NQO1 in sta...
Autores principales: | Oh, Eun-Taex, Kim, Jung-whan, Kim, Joon Mee, Kim, Soo Jung, Lee, Jae-Seon, Hong, Soon-Sun, Goodwin, Justin, Ruthenborg, Robin J., Jung, Myung Gu, Lee, Hae-June, Lee, Chul-Ho, Park, Eun Sung, Kim, Chulhee, Park, Heon Joo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171868/ https://www.ncbi.nlm.nih.gov/pubmed/27966538 http://dx.doi.org/10.1038/ncomms13593 |
Ejemplares similares
-
NQO1 regulates cell cycle progression at the G2/M phase
por: Oh, Eun-Taex, et al.
Publicado: (2023) -
Implications of NQO1 in cancer therapy
por: Oh, Eun-Taex, et al.
Publicado: (2015) -
Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
por: Oh, Eun-Taex, et al.
Publicado: (2016) -
NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation
por: Lee, Hyemi, et al.
Publicado: (2015) -
Tuning of Peptide
Cytotoxicity with Cell Penetrating
Motif Activatable by Matrix Metalloproteinase-2
por: Lee, Jeonghun, et al.
Publicado: (2022)