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Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein

The prototypic β-herpesvirus human cytomegalovirus (CMV) establishes life-long persistence within its human host. The CMV envelope consists of various protein complexes that enable wide viral tropism. More specifically, the glycoprotein complex gH/gL/gO (gH-trimer) is required for infection of all c...

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Detalles Bibliográficos
Autores principales:	Gardner, Thomas J., Stein, Kathryn R., Duty, J. Andrew, Schwarz, Toni M., Noriega, Vanessa M., Kraus, Thomas, Moran, Thomas M., Tortorella, Domenico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171902/ https://www.ncbi.nlm.nih.gov/pubmed/27966523 http://dx.doi.org/10.1038/ncomms13627

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