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Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

Accumulation of amyloid-β (Aβ) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer’s disease (AD). The precise pathological species of Aβ remains elusive although evidence suggests soluble oligomers may be primarily responsible for neurotoxicity. Crenezumab is a hum...

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Detalles Bibliográficos
Autores principales:	Ultsch, Mark, Li, Bing, Maurer, Till, Mathieu, Mary, Adolfsson, Oskar, Muhs, Andreas, Pfeifer, Andrea, Pihlgren, Maria, Bainbridge, Travis W., Reichelt, Mike, Ernst, James A., Eigenbrot, Charles, Fuh, Germaine, Atwal, Jasvinder K., Watts, Ryan J., Wang, Weiru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171940/ https://www.ncbi.nlm.nih.gov/pubmed/27996029 http://dx.doi.org/10.1038/srep39374

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