Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

Differentiation and homeostasis of natural killer (NK) cells relies on common gamma-chain (γc)-dependent cytokines, in particular IL-15. Consequently, NK cells do not develop in mice with targeted γc deletion. Herein we identify an alternative pathway of NK-cell development driven by the proinflamma...

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Detalles Bibliográficos
Autores principales: Ohs, Isabel, van den Broek, Maries, Nussbaum, Kathrin, Münz, Christian, Arnold, Sebastian J., Quezada, Sergio A., Tugues, Sonia, Becher, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172358/
https://www.ncbi.nlm.nih.gov/pubmed/27982126
http://dx.doi.org/10.1038/ncomms13708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172358/
https://www.ncbi.nlm.nih.gov/pubmed/27982126
http://dx.doi.org/10.1038/ncomms13708

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