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Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
Differentiation and homeostasis of natural killer (NK) cells relies on common gamma-chain (γc)-dependent cytokines, in particular IL-15. Consequently, NK cells do not develop in mice with targeted γc deletion. Herein we identify an alternative pathway of NK-cell development driven by the proinflamma...
Autores principales: | Ohs, Isabel, van den Broek, Maries, Nussbaum, Kathrin, Münz, Christian, Arnold, Sebastian J., Quezada, Sergio A., Tugues, Sonia, Becher, Burkhard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172358/ https://www.ncbi.nlm.nih.gov/pubmed/27982126 http://dx.doi.org/10.1038/ncomms13708 |
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