Cargando…
A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China
We report a complete genomic sequence of rare isolates (minor genotype) of the SARS-CoV from SARS patients in Guangdong, China, where the first few cases emerged. The most striking discovery from the isolate is an extra 29-nucleotide sequence located at the nucleotide positions between 27,863 and 27...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2003
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172408/ https://www.ncbi.nlm.nih.gov/pubmed/15626340 http://dx.doi.org/10.1016/S1672-0229(03)01014-3 |
| _version_ | 1782484123800043520 |
|---|---|
| author | Qin, E’de He, Xionglei Tian, Wei Liu, Yong Li, Wei Wen, Jie Wang, Jingqiang Fan, Baochang Wu, Qingfa Chang, Guohui Cao, Wuchun Xu, Zuyuan Yang, Ruifu Wang, Jing Yu, Man Li, Yan Xu, Jing Si, Bingyin Hu, Yongwu Peng, Wenming Tang, Lin Jiang, Tao Shi, Jianping Ji, Jia Zhang, Yu Ye, Jia Wang, Cui’e Han, Yujun Zhou, Jun Deng, Yajun Li, Xiaoyu Hu, Jianfei Wang, Caiping Yan, Chunxia Zhang, Qingrun Bao, Jingyue Li, Guoqing Chen, Weijun Fang, Lin Li, Changfeng Lei, Meng Li, Dawei Tong, Wei Tian, Xiangjun Wang, Jin Zhang, Bo Zhang, Haiqing Zhang, Yilin Zhao, Hui Zhang, Xiaowei Li, Shuangli Cheng, Xiaojie Zhang, Xiuqing Liu, Bin Zeng, Changqing Li, Songgang Tan, Xuehai Liu, Siqi Dong, Wei Wang, Jun Wong, Gane Ka-Shu Yu, Jun Wang, Jian Zhu, Qingyu Yang, Huanming |
| author_facet | Qin, E’de He, Xionglei Tian, Wei Liu, Yong Li, Wei Wen, Jie Wang, Jingqiang Fan, Baochang Wu, Qingfa Chang, Guohui Cao, Wuchun Xu, Zuyuan Yang, Ruifu Wang, Jing Yu, Man Li, Yan Xu, Jing Si, Bingyin Hu, Yongwu Peng, Wenming Tang, Lin Jiang, Tao Shi, Jianping Ji, Jia Zhang, Yu Ye, Jia Wang, Cui’e Han, Yujun Zhou, Jun Deng, Yajun Li, Xiaoyu Hu, Jianfei Wang, Caiping Yan, Chunxia Zhang, Qingrun Bao, Jingyue Li, Guoqing Chen, Weijun Fang, Lin Li, Changfeng Lei, Meng Li, Dawei Tong, Wei Tian, Xiangjun Wang, Jin Zhang, Bo Zhang, Haiqing Zhang, Yilin Zhao, Hui Zhang, Xiaowei Li, Shuangli Cheng, Xiaojie Zhang, Xiuqing Liu, Bin Zeng, Changqing Li, Songgang Tan, Xuehai Liu, Siqi Dong, Wei Wang, Jun Wong, Gane Ka-Shu Yu, Jun Wang, Jian Zhu, Qingyu Yang, Huanming |
| author_sort | Qin, E’de |
| collection | PubMed |
| description | We report a complete genomic sequence of rare isolates (minor genotype) of the SARS-CoV from SARS patients in Guangdong, China, where the first few cases emerged. The most striking discovery from the isolate is an extra 29-nucleotide sequence located at the nucleotide positions between 27,863 and 27,864 (referred to the complete sequence of BJ01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream of the N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29, suggests a significant genetic event and differentiates it from the previously reported genotype, the dominant form among all sequenced SARS-CoV isolates. A 17-nt segment of this extra sequence is identical to a segment of the same size in two human mRNA sequences that may interfere with viral genome replication and transcription in the cytosol of the infected cells. It provides a new avenue for the exploration of the virus-host interaction in viral evolution, host pathogenesis, and vaccine development. |
| format | Online Article Text |
| id | pubmed-5172408 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2003 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-51724082016-12-23 A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China Qin, E’de He, Xionglei Tian, Wei Liu, Yong Li, Wei Wen, Jie Wang, Jingqiang Fan, Baochang Wu, Qingfa Chang, Guohui Cao, Wuchun Xu, Zuyuan Yang, Ruifu Wang, Jing Yu, Man Li, Yan Xu, Jing Si, Bingyin Hu, Yongwu Peng, Wenming Tang, Lin Jiang, Tao Shi, Jianping Ji, Jia Zhang, Yu Ye, Jia Wang, Cui’e Han, Yujun Zhou, Jun Deng, Yajun Li, Xiaoyu Hu, Jianfei Wang, Caiping Yan, Chunxia Zhang, Qingrun Bao, Jingyue Li, Guoqing Chen, Weijun Fang, Lin Li, Changfeng Lei, Meng Li, Dawei Tong, Wei Tian, Xiangjun Wang, Jin Zhang, Bo Zhang, Haiqing Zhang, Yilin Zhao, Hui Zhang, Xiaowei Li, Shuangli Cheng, Xiaojie Zhang, Xiuqing Liu, Bin Zeng, Changqing Li, Songgang Tan, Xuehai Liu, Siqi Dong, Wei Wang, Jun Wong, Gane Ka-Shu Yu, Jun Wang, Jian Zhu, Qingyu Yang, Huanming Genomics Proteomics Bioinformatics Article We report a complete genomic sequence of rare isolates (minor genotype) of the SARS-CoV from SARS patients in Guangdong, China, where the first few cases emerged. The most striking discovery from the isolate is an extra 29-nucleotide sequence located at the nucleotide positions between 27,863 and 27,864 (referred to the complete sequence of BJ01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream of the N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29, suggests a significant genetic event and differentiates it from the previously reported genotype, the dominant form among all sequenced SARS-CoV isolates. A 17-nt segment of this extra sequence is identical to a segment of the same size in two human mRNA sequences that may interfere with viral genome replication and transcription in the cytosol of the infected cells. It provides a new avenue for the exploration of the virus-host interaction in viral evolution, host pathogenesis, and vaccine development. Elsevier 2003-05 2016-11-28 /pmc/articles/PMC5172408/ /pubmed/15626340 http://dx.doi.org/10.1016/S1672-0229(03)01014-3 Text en . http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Qin, E’de He, Xionglei Tian, Wei Liu, Yong Li, Wei Wen, Jie Wang, Jingqiang Fan, Baochang Wu, Qingfa Chang, Guohui Cao, Wuchun Xu, Zuyuan Yang, Ruifu Wang, Jing Yu, Man Li, Yan Xu, Jing Si, Bingyin Hu, Yongwu Peng, Wenming Tang, Lin Jiang, Tao Shi, Jianping Ji, Jia Zhang, Yu Ye, Jia Wang, Cui’e Han, Yujun Zhou, Jun Deng, Yajun Li, Xiaoyu Hu, Jianfei Wang, Caiping Yan, Chunxia Zhang, Qingrun Bao, Jingyue Li, Guoqing Chen, Weijun Fang, Lin Li, Changfeng Lei, Meng Li, Dawei Tong, Wei Tian, Xiangjun Wang, Jin Zhang, Bo Zhang, Haiqing Zhang, Yilin Zhao, Hui Zhang, Xiaowei Li, Shuangli Cheng, Xiaojie Zhang, Xiuqing Liu, Bin Zeng, Changqing Li, Songgang Tan, Xuehai Liu, Siqi Dong, Wei Wang, Jun Wong, Gane Ka-Shu Yu, Jun Wang, Jian Zhu, Qingyu Yang, Huanming A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China |
| title | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China |
| title_full | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China |
| title_fullStr | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China |
| title_full_unstemmed | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China |
| title_short | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China |
| title_sort | genome sequence of novel sars-cov isolates: the genotype, gd-ins29, leads to a hypothesis of viral transmission in south china |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172408/ https://www.ncbi.nlm.nih.gov/pubmed/15626340 http://dx.doi.org/10.1016/S1672-0229(03)01014-3 |
| work_keys_str_mv | AT qinede agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT hexionglei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tianwei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liuyong agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liwei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wenjie agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjingqiang agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT fanbaochang agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wuqingfa agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT changguohui agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT caowuchun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT xuzuyuan agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yangruifu agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjing agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yuman agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liyan agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT xujing agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT sibingyin agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT huyongwu agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT pengwenming agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tanglin agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT jiangtao agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT shijianping agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT jijia agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangyu agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yejia agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangcuie agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT hanyujun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhoujun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT dengyajun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lixiaoyu agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT hujianfei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangcaiping agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yanchunxia agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangqingrun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT baojingyue agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liguoqing agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT chenweijun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT fanglin agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lichangfeng agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT leimeng agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lidawei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tongwei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tianxiangjun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjin agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangbo agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhanghaiqing agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangyilin agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhaohui agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangxiaowei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lishuangli agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT chengxiaojie agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangxiuqing agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liubin agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zengchangqing agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lisonggang agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tanxuehai agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liusiqi agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT dongwei agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wongganekashu agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yujun agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjian agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhuqingyu agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yanghuanming agenomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT qinede genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT hexionglei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tianwei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liuyong genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liwei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wenjie genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjingqiang genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT fanbaochang genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wuqingfa genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT changguohui genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT caowuchun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT xuzuyuan genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yangruifu genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjing genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yuman genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liyan genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT xujing genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT sibingyin genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT huyongwu genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT pengwenming genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tanglin genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT jiangtao genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT shijianping genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT jijia genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangyu genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yejia genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangcuie genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT hanyujun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhoujun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT dengyajun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lixiaoyu genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT hujianfei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangcaiping genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yanchunxia genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangqingrun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT baojingyue genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liguoqing genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT chenweijun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT fanglin genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lichangfeng genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT leimeng genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lidawei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tongwei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tianxiangjun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjin genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangbo genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhanghaiqing genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangyilin genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhaohui genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangxiaowei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lishuangli genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT chengxiaojie genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhangxiuqing genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liubin genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zengchangqing genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT lisonggang genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT tanxuehai genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT liusiqi genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT dongwei genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wongganekashu genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yujun genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT wangjian genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT zhuqingyu genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina AT yanghuanming genomesequenceofnovelsarscovisolatesthegenotypegdins29leadstoahypothesisofviraltransmissioninsouthchina |