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Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen

Monolayer culture is integral to many cell‐based cartilage repair strategies, but chondrocytes lose regenerative potential with increasing duration in vitro. This coincides with elevated reactive oxygen species (ROS) levels and a bioenergetic transformation characterized by increasing mitochondrial...

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Detalles Bibliográficos
Autores principales: Heywood, H. K., Lee, D. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172424/
https://www.ncbi.nlm.nih.gov/pubmed/26799635
http://dx.doi.org/10.1002/term.2126