Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host cells. The mechanisms underpinning this key intrace...

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Detalles Bibliográficos
Autores principales: Fineran, Paul, Lloyd-Evans, Emyr, Lack, Nathan A., Platt, Nick, Davis, Lianne C., Morgan, Anthony J., Höglinger, Doris, Tatituri, Raju Venkata V., Clark, Simon, Williams, Ian M., Tynan, Patricia, Al Eisa, Nada, Nazarova, Evgeniya, Williams, Ann, Galione, Antony, Ory, Daniel S., Besra, Gurdyal S., Russell, David G., Brenner, Michael B., Sim, Edith, Platt, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172425/
https://www.ncbi.nlm.nih.gov/pubmed/28008422
http://dx.doi.org/10.12688/wellcomeopenres.10036.2

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