Structure Prediction of Membrane Proteins

There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding...

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Detalles Bibliográficos
Autores principales: Zhou, Chunlong, Zheng, Yao, Zhou, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2004
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172438/
https://www.ncbi.nlm.nih.gov/pubmed/15629037
http://dx.doi.org/10.1016/S1672-0229(04)02001-7
Descripción
Sumario:There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding of the function of an MP and the interactions between the protein and its inhibitors or activators. In this paper, some computational approaches that have been used to predict MP structures are discussed and compared.

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