Structure Prediction of Membrane Proteins

There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding...

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Detalles Bibliográficos
Autores principales: Zhou, Chunlong, Zheng, Yao, Zhou, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2004
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172438/
https://www.ncbi.nlm.nih.gov/pubmed/15629037
http://dx.doi.org/10.1016/S1672-0229(04)02001-7
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author Zhou, Chunlong
Zheng, Yao
Zhou, Yan
author_facet Zhou, Chunlong
Zheng, Yao
Zhou, Yan
author_sort Zhou, Chunlong
collection PubMed
description There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding of the function of an MP and the interactions between the protein and its inhibitors or activators. In this paper, some computational approaches that have been used to predict MP structures are discussed and compared.
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spelling pubmed-51724382016-12-23 Structure Prediction of Membrane Proteins Zhou, Chunlong Zheng, Yao Zhou, Yan Genomics Proteomics Bioinformatics Review There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding of the function of an MP and the interactions between the protein and its inhibitors or activators. In this paper, some computational approaches that have been used to predict MP structures are discussed and compared. Elsevier 2004-02 2016-11-28 /pmc/articles/PMC5172438/ /pubmed/15629037 http://dx.doi.org/10.1016/S1672-0229(04)02001-7 Text en . http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhou, Chunlong
Zheng, Yao
Zhou, Yan
Structure Prediction of Membrane Proteins
title Structure Prediction of Membrane Proteins
title_full Structure Prediction of Membrane Proteins
title_fullStr Structure Prediction of Membrane Proteins
title_full_unstemmed Structure Prediction of Membrane Proteins
title_short Structure Prediction of Membrane Proteins
title_sort structure prediction of membrane proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172438/
https://www.ncbi.nlm.nih.gov/pubmed/15629037
http://dx.doi.org/10.1016/S1672-0229(04)02001-7
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