Construction of A Non-Redundant Human SH2 Domain Database

Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we report the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins....

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Haiming, Jiao, Yuchen, Xu, Rui, Gao, Youhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2004
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172440/
https://www.ncbi.nlm.nih.gov/pubmed/15629051
http://dx.doi.org/10.1016/S1672-0229(04)02017-0
_version_ 1782484129879687168
author Huang, Haiming
Jiao, Yuchen
Xu, Rui
Gao, Youhe
author_facet Huang, Haiming
Jiao, Yuchen
Xu, Rui
Gao, Youhe
author_sort Huang, Haiming
collection PubMed
description Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we report the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree was generated. In this tree, proteins with similar known function were classified into the same group. Some proteins in the same group have been reported to have similar binding motifs experimentally. The tree might provide clues about possible functions of hypothetical proteins for further experimental verification.
format Online
Article
Text
id pubmed-5172440
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-51724402016-12-23 Construction of A Non-Redundant Human SH2 Domain Database Huang, Haiming Jiao, Yuchen Xu, Rui Gao, Youhe Genomics Proteomics Bioinformatics Brief Report Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we report the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree was generated. In this tree, proteins with similar known function were classified into the same group. Some proteins in the same group have been reported to have similar binding motifs experimentally. The tree might provide clues about possible functions of hypothetical proteins for further experimental verification. Elsevier 2004-05 2016-11-28 /pmc/articles/PMC5172440/ /pubmed/15629051 http://dx.doi.org/10.1016/S1672-0229(04)02017-0 Text en . http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Report
Huang, Haiming
Jiao, Yuchen
Xu, Rui
Gao, Youhe
Construction of A Non-Redundant Human SH2 Domain Database
title Construction of A Non-Redundant Human SH2 Domain Database
title_full Construction of A Non-Redundant Human SH2 Domain Database
title_fullStr Construction of A Non-Redundant Human SH2 Domain Database
title_full_unstemmed Construction of A Non-Redundant Human SH2 Domain Database
title_short Construction of A Non-Redundant Human SH2 Domain Database
title_sort construction of a non-redundant human sh2 domain database
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172440/
https://www.ncbi.nlm.nih.gov/pubmed/15629051
http://dx.doi.org/10.1016/S1672-0229(04)02017-0
work_keys_str_mv AT huanghaiming constructionofanonredundanthumansh2domaindatabase
AT jiaoyuchen constructionofanonredundanthumansh2domaindatabase
AT xurui constructionofanonredundanthumansh2domaindatabase
AT gaoyouhe constructionofanonredundanthumansh2domaindatabase

Ejemplares similares