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A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)

To investigate genetic mechanisms of high altitude adaptations of native mammals on the Tibetan Plateau, we compared mitochondrial sequences of the endangered Pantholops hodgsonii with its lowland distant relatives Ovis aries and Capra hircus, as well as other mammals. The complete mitochondrial gen...

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Detalles Bibliográficos
Autores principales: Xu, Shu-Qing, Yang, Ying-Zhong, Zhou, Jun, Jin, Guo-En, Chen, Yun-Tian, Wang, Jun, Yang, Huan-Ming, Wang, Jian, Yu, Jun, Zheng, Xiao-Guang, Ge, Ri-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172476/
https://www.ncbi.nlm.nih.gov/pubmed/16144518
http://dx.doi.org/10.1016/S1672-0229(05)03003-2
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author Xu, Shu-Qing
Yang, Ying-Zhong
Zhou, Jun
Jin, Guo-En
Chen, Yun-Tian
Wang, Jun
Yang, Huan-Ming
Wang, Jian
Yu, Jun
Zheng, Xiao-Guang
Ge, Ri-Li
author_facet Xu, Shu-Qing
Yang, Ying-Zhong
Zhou, Jun
Jin, Guo-En
Chen, Yun-Tian
Wang, Jun
Yang, Huan-Ming
Wang, Jian
Yu, Jun
Zheng, Xiao-Guang
Ge, Ri-Li
author_sort Xu, Shu-Qing
collection PubMed
description To investigate genetic mechanisms of high altitude adaptations of native mammals on the Tibetan Plateau, we compared mitochondrial sequences of the endangered Pantholops hodgsonii with its lowland distant relatives Ovis aries and Capra hircus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii (16,498 bp) revealed a similar gene order as of other mammals. Because of tandem duplications, the control region of P. hodgsonii mitochondrial genome is shorter than those of O. aries and C. hircus, but longer than those of Bos species. Phylogenetic analysis based on alignments of the entire cytochrome b genes suggested that P. hodgsonii is more closely related to O. aries and C. hircus, rather than to species of the Antilopinae subfamily. The estimated divergence time between P. hodgsonii and O. aries is about 2.25 million years ago. Further analysis on natural selection indicated that the COXI (cytochrome c oxidase subunit I) gene was under positive selection in P. hodgsonii and Bos grunniens. Considering the same climates and environments shared by these two mammalian species, we proposed that the mitochondrial COXI gene is probably relevant for these native mammals to adapt the high altitude environment unique to the Tibetan Plateau.
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spelling pubmed-51724762016-12-23 A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii) Xu, Shu-Qing Yang, Ying-Zhong Zhou, Jun Jin, Guo-En Chen, Yun-Tian Wang, Jun Yang, Huan-Ming Wang, Jian Yu, Jun Zheng, Xiao-Guang Ge, Ri-Li Genomics Proteomics Bioinformatics Article To investigate genetic mechanisms of high altitude adaptations of native mammals on the Tibetan Plateau, we compared mitochondrial sequences of the endangered Pantholops hodgsonii with its lowland distant relatives Ovis aries and Capra hircus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii (16,498 bp) revealed a similar gene order as of other mammals. Because of tandem duplications, the control region of P. hodgsonii mitochondrial genome is shorter than those of O. aries and C. hircus, but longer than those of Bos species. Phylogenetic analysis based on alignments of the entire cytochrome b genes suggested that P. hodgsonii is more closely related to O. aries and C. hircus, rather than to species of the Antilopinae subfamily. The estimated divergence time between P. hodgsonii and O. aries is about 2.25 million years ago. Further analysis on natural selection indicated that the COXI (cytochrome c oxidase subunit I) gene was under positive selection in P. hodgsonii and Bos grunniens. Considering the same climates and environments shared by these two mammalian species, we proposed that the mitochondrial COXI gene is probably relevant for these native mammals to adapt the high altitude environment unique to the Tibetan Plateau. Elsevier 2005 2016-11-28 /pmc/articles/PMC5172476/ /pubmed/16144518 http://dx.doi.org/10.1016/S1672-0229(05)03003-2 Text en . http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Xu, Shu-Qing
Yang, Ying-Zhong
Zhou, Jun
Jin, Guo-En
Chen, Yun-Tian
Wang, Jun
Yang, Huan-Ming
Wang, Jian
Yu, Jun
Zheng, Xiao-Guang
Ge, Ri-Li
A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)
title A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)
title_full A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)
title_fullStr A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)
title_full_unstemmed A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)
title_short A Mitochondrial Genome Sequence of the Tibetan Antelope (Pantholops hodgsonii)
title_sort mitochondrial genome sequence of the tibetan antelope (pantholops hodgsonii)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172476/
https://www.ncbi.nlm.nih.gov/pubmed/16144518
http://dx.doi.org/10.1016/S1672-0229(05)03003-2
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