Time-Dependent Regulation of IL-2R α-Chain (CD25) Expression by TCR Signal Strength and IL-2-Induced STAT5 Signaling in Activated Human Blood T Lymphocytes

The expression of the IL-2R α-chain (IL-2Rα) is regulated at the transcriptional level via TCR- and IL-2R-signaling. The question is how to precede in time the activation signals to induce the IL-2Rα expression in native primary T cells. By comparing the effects of selective drugs on the dynamics of...

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Detalles Bibliográficos
Autores principales: Shatrova, Alla N., Mityushova, Elena V., Vassilieva, Irina O., Aksenov, Nikolay D., Zenin, Valery V., Nikolsky, Nikolay N., Marakhova, Irina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172478/
https://www.ncbi.nlm.nih.gov/pubmed/27936140
http://dx.doi.org/10.1371/journal.pone.0167215

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