Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome

Neuroblastoma is characterized by a relative paucity of recurrent somatic mutations at diagnosis. However, recent studies have shown that the mutational burden increases at relapse, likely as a result of clonal evolution of mutation-carrying cells during primary treatment. To inform the development...

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Detalles Bibliográficos
Autores principales: Padovan-Merhar, Olivia M., Raman, Pichai, Ostrovnaya, Irina, Kalletla, Karthik, Rubnitz, Kaitlyn R., Sanford, Eric M., Ali, Siraj M., Miller, Vincent A., Mossé, Yael P., Granger, Meaghan P., Weiss, Brian, Maris, John M., Modak, Shakeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172533/
https://www.ncbi.nlm.nih.gov/pubmed/27997549
http://dx.doi.org/10.1371/journal.pgen.1006501

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