Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia

Familial Dysautonomia (FD) is a neurodegenerative disease in which aberrant tissue-specific splicing of IKBKAP exon 20 leads to reduction of IKAP protein levels in neuronal tissues. Here we generated a conditional knockout (CKO) mouse in which exon 20 of IKBKAP is deleted in the nervous system. The...

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Detalles Bibliográficos
Autores principales: Naftelberg, Shiran, Abramovitch, Ziv, Gluska, Shani, Yannai, Sivan, Joshi, Yuvraj, Donyo, Maya, Ben-Yaakov, Keren, Gradus, Tal, Zonszain, Jonathan, Farhy, Chen, Ashery-Padan, Ruth, Perlson, Eran, Ast, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172536/
https://www.ncbi.nlm.nih.gov/pubmed/27997532
http://dx.doi.org/10.1371/journal.pgen.1006486

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