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Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production

Type I interferons (IFN-α/β) play a key role in antiviral defense, and porcine reproductive and respiratory syndrome virus (PRRSV) is known to down-regulate the IFN response in virus-infected cells and pigs. In this study, we showed that the overexpression of nsp11 of PRRSV induced a strong suppress...

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Detalles Bibliográficos
Autores principales:	Sun, Yan, Ke, Hanzhong, Han, Mingyuan, Chen, Ning, Fang, Weihuan, Yoo, Dongwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172586/ https://www.ncbi.nlm.nih.gov/pubmed/27997564 http://dx.doi.org/10.1371/journal.pone.0168314

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