Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia

In Chronic Lymphocytic Leukemia (CLL), infiltration of lymph nodes by leukemic cells is observed in patients with progressive disease and adverse outcome. We have previously demonstrated that B-cell receptor (BCR) engagement resulted in CXCR4 down-regulation in CLL cells, correlating with a shorter...

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Detalles Bibliográficos
Autores principales: Saint-Georges, Stéphane, Quettier, Maude, Bouyaba, Marouane, Le Coquil, Stéphanie, Laurienté, Vanessa, Guittat, Lionel, Lévy, Vincent, Ajchenbaum-Cymbalista, Florence, Varin-Blank, Nadine, Le Roy, Christine, Ledoux, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173040/
https://www.ncbi.nlm.nih.gov/pubmed/27127886
http://dx.doi.org/10.18632/oncotarget.9031

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