Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside

There are still unmet medical needs in the treatment of glioblastoma, the most common and the most aggressive glioma of all brain tumors. Here, we found that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue. In addition, we demonstrated that 8B6 monoclonal antibody specific...

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Autores principales: Fleurence, Julien, Cochonneau, Denis, Fougeray, Sophie, Oliver, Lisa, Geraldo, Fanny, Terme, Mickaël, Dorvillius, Mylène, Loussouarn, Delphine, Vallette, François, Paris, François, Birklé, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173050/
https://www.ncbi.nlm.nih.gov/pubmed/27172791
http://dx.doi.org/10.18632/oncotarget.9226
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author Fleurence, Julien
Cochonneau, Denis
Fougeray, Sophie
Oliver, Lisa
Geraldo, Fanny
Terme, Mickaël
Dorvillius, Mylène
Loussouarn, Delphine
Vallette, François
Paris, François
Birklé, Stéphane
author_facet Fleurence, Julien
Cochonneau, Denis
Fougeray, Sophie
Oliver, Lisa
Geraldo, Fanny
Terme, Mickaël
Dorvillius, Mylène
Loussouarn, Delphine
Vallette, François
Paris, François
Birklé, Stéphane
author_sort Fleurence, Julien
collection PubMed
description There are still unmet medical needs in the treatment of glioblastoma, the most common and the most aggressive glioma of all brain tumors. Here, we found that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue. In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylat GD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Taken together, these results indicate that O-acetylated GD2 represents a novel antigen for immunotherapeutic-based treatment of high-grade gliomas.
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spelling pubmed-51730502016-12-23 Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside Fleurence, Julien Cochonneau, Denis Fougeray, Sophie Oliver, Lisa Geraldo, Fanny Terme, Mickaël Dorvillius, Mylène Loussouarn, Delphine Vallette, François Paris, François Birklé, Stéphane Oncotarget Research Paper There are still unmet medical needs in the treatment of glioblastoma, the most common and the most aggressive glioma of all brain tumors. Here, we found that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue. In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylat GD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Taken together, these results indicate that O-acetylated GD2 represents a novel antigen for immunotherapeutic-based treatment of high-grade gliomas. Impact Journals LLC 2016-05-09 /pmc/articles/PMC5173050/ /pubmed/27172791 http://dx.doi.org/10.18632/oncotarget.9226 Text en Copyright: © 2016 Fleurence et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Fleurence, Julien
Cochonneau, Denis
Fougeray, Sophie
Oliver, Lisa
Geraldo, Fanny
Terme, Mickaël
Dorvillius, Mylène
Loussouarn, Delphine
Vallette, François
Paris, François
Birklé, Stéphane
Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
title Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
title_full Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
title_fullStr Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
title_full_unstemmed Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
title_short Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
title_sort targeting and killing glioblastoma with monoclonal antibody to o-acetyl gd2 ganglioside
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173050/
https://www.ncbi.nlm.nih.gov/pubmed/27172791
http://dx.doi.org/10.18632/oncotarget.9226
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